Evidence map›Paper›PMID 40305051›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Comparative single-cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination.

UnJin Lee, Cong Li, Christopher B Langer, Nicolas Svetec, Li Zhao

Abstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. De Novo Genes: Current Status and Future Goals.Genome biology and evolution · 2025
    Article
  4. Dichotomous transcriptome divergence at the cell-type level between thebioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

UnJin LeeLaboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY 10065.ORCID 0000-0003-2424-650X
Cong LiLaboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY 10065.ORCID 0009-0008-5255-5215
Christopher B LangerLaboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY 10065.
Nicolas SvetecLaboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-9617-2752
Li ZhaoLaboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-6776-1996

Funding

The genetic and epigenetic mechanisms of phenotypic innovationhttps://apps.era.nih.gov/gm/reportCheckList.do?applicationID=9798249R35GM133780 · NIGMS · ROCKEFELLER UNIVERSITY · PI Li Zhao · 2019 to 2026
$3.5M
AI | Paul G. Allen Frontiers Group (The Frontiers Group) NAHHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM133780NIGMS NIH HHS R35 GM133780NSF | BIO | Division of Biological Infrastructure (DBI) 2410289Robertson Foundation (The Robertson Foundation) NA
6 · The paper itself

Abstract

Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the

Indexed as

Genome, InsectSingle-Cell AnalysisSpermatogenesisTranscription, GeneticAnimalsDrosophilaDrosophila melanogasterEvolution, MolecularMaleSpecies SpecificityTestisTranscriptomede novo genesDrosophilasingle-cell RNA-seqtestistranscriptional divergence

Identifiers

PMID40305051
PMCPMC12067204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.