Transcriptomic analysis of inhibitory effects of isothiazolone antimicrobial agents on Aspergillus amstelodami ZR.

Junyu Tang, Qizhao Liang, Rui Zhang, Xiaoping Huang

Abstract read

In one paragraph

Article in Journal of applied genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

4 authors.

Junyu Tang *College of Food Science, Guangdong Ocean University, Zhanjiang, 524088, Guangdong, China.

Qizhao Liang *College of Food Science, Guangdong Ocean University, Zhanjiang, 524088, Guangdong, China.

Rui ZhangCollege of Food Science, Guangdong Ocean University, Zhanjiang, 524088, Guangdong, China. 157761969@qq.com.

Xiaoping HuangSchool of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian, China.

Funding

Guangdong provincial innovation and entrepreneurship training program for college students CXXL2017039Industrial development special fund project of Shenzhen Dapeng New District KY20180204

6 · The paper itself

Abstract

The preservation of marine specimens requires effective methods to ensure research accuracy and ecological sustainability. However, conventional preservatives (e.g., formaldehyde) pose environmental and health risks due to their toxicity. In this study, we isolated Aspergillus amstelodami from the surface of Oreochromis mossambicus specimens and evaluated the antifungal potential of 1,2-benzoisothiazolin-3-one and Kathon. Both agents exhibited strong inhibitory effects on fungal growth, as evidenced by clear inhibition zones. Transcriptomic analysis revealed: (1) upregulation of detoxification-related genes, including cytochrome P450-mediated xenobiotic/drug metabolism, ABC transporters, and two-component systems, and (2) downregulation of ribosome biogenesis genes, impairing protein synthesis in Aspergillus amstelodami. In conclusion, this study provides novel insights into the molecular antifungal mechanisms of isothiazolone antimicrobial agents in combating contamination of marine biological specimens caused by Aspergillus amstelodami.

Indexed as

Antifungal AgentsAnti-Infective AgentsAspergillusThiazolesTranscriptomeAnimalsGene Expression ProfilingGene Expression Regulation, FungalAntifungal AgentsAnti-Infective AgentsThiazolesAntifungal activityAspergillus amstelodamiIsothiazolone antimicrobial agentsMarine specimenMolecular antifungal mechanisms

Identifiers

PMID40304973

DOI10.1007/s13353-025-00969-1

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.