Evidence map›Paper›PMID 40304866›Full record

ArticleJournal of cancer survivorship : research and practice2025

Cross-sectional associations of proteomic age acceleration with self-reported physical and mental health and depression symptoms among those with and without cancer.

Matia Solomon, R Bhatia, S Wang, A H Blaes, E A Platz, W Guan, P I Jewett, A Prizment

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Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Matia SolomonSchool of Medicine, University of Minnesota, Minneapolis, MN, USA. solom264@umn.edu.
R BhatiaUniversity of Michigan, Ann Arbor, MI, USA.
S WangDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.
A H BlaesSchool of Medicine, University of Minnesota, Minneapolis, MN, USA.
E A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
W GuanDivision of Biostatistics & Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
P I Jewett *Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
A Prizment *Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
Proteomic aging in adults before and after cancer diagnosisR01CA267977 · NCI · UNIVERSITY OF MINNESOTA · PI PRIZMENT, ANNA · 2022 to 2024
$1.0M
NCATS NIH HHS UM1TR004405NCI NIH HHS R01 CA267977NCI NIH HHS R01CA267977
6 · The paper itself

Abstract

purposeAccelerated aging may affect quality of life (QOL), and having cancer may further complicate that relationship. We assessed the cross-sectional association of a novel proteomic aging clock (PAC) with self-reported physical and mental health and depression symptoms among individuals with and without cancer.

methodsData for this cross-sectional analysis came from the prospective Atherosclerosis Risk in Communities (ARIC) Study. We estimated proteomic age acceleration (PAA), i.e., the deviation of PAC from chronological age, at two ARIC visits (1990-1992 and 2011-2013). We used linear regression models to estimate the association of PAA and change in PAA with self-reported physical (PCS) and mental health (MCS) as well as depression symptoms, separately for cancer survivors and individuals without cancer.

resultsAmong cancer survivors, mean PCS, MCS, and depression scores were 44.0, 54.8, and 6.7, respectively; and 46.6, 55.3, and 6.5 among those without a cancer history. PAA was associated with lower PCS (adjusted coefficients per additional 5 years; cancer survivors, - 1.73, 95% CI - 3.11, - 0.35; without a cancer history, - 2.70, 95% CI - 3.90, - 1.51) and with higher depression scores among those without a cancer history (0.57, 95% CI 0.27, 0.88). Neither PAA nor change in PAA was associated with MCS in either population.

conclusionWe found some evidence for a cross-sectional association of PAA with self-reported physical health, but little evidence for an association with mental health and depression scores. IMPLICATIONS FOR CANCER SURVIVORS: PAA may have stronger implications for physical than for mental health outcomes among those with and without cancer.

Indexed as

Age accelerationCancer survivorCross-sectionalDepressionProteomic ageQuality of life

Identifiers

PMID40304866

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