Evidence map›Paper›PMID 40304857›Full record

ArticleMolecular imaging and biology2025

Species-Specific Hepatic Uptake of [

Jinda Fan, Bijja Janaki Ramulu, Christiane L Mallett, Legend E Kenney, Nathan Kauffman, Tapas Bhattacharyya, Maryam Sabbaghan, Satyendra Singh, Kurt R Zinn, Erik M Shapiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinda FanDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA. fanjinda@msu.edu.
Bijja Janaki RamuluDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA.
Christiane L MallettDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA.
Legend E KenneyDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA.
Nathan KauffmanDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.
Tapas BhattacharyyaDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA.
Maryam SabbaghanDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA.
Satyendra SinghDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA.
Kurt R ZinnDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA.
Erik M ShapiroDepartment of Radiology, Michigan State University, 846 Service Rd, East Lansing, MI, 48824, USA. shapir86@msu.edu.ORCID http://orcid.org/0000-0002-0901-5781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMeasuring hepatic flux rates of transportable substrates has the potential for assessing liver function. PET imaging of a PET-enabled substrate may provide a more straightforward measurement of time-dependent substrate concentration through the liver than MRI using an MRI contrast agent. Here we synthesized and evaluated the hepatobiliary transport of a new hepatospecific PET agent designed for stable Cu PROCEDURES: EOB-NOTA was synthesized, its two enantiomers separated by chiral HPLC, and individually radiolabeled with [

resultsIn wild-type mice, [

conclusion[

Indexed as

Copper RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingLiverPositron-Emission TomographyAnimalsBiological TransportHumansMagnetic Resonance ImagingMiceSpecies SpecificityTissue Distribution1,4,7-triazacyclononane-N,N',N''-triacetic acidCopper-64Copper RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingCopperLiverMouseMRIPET imaging

Identifiers

PMID40304857
PMCPMC12162674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.