Evidence map›Paper›PMID 40304824›Full record

SynthesisCurrent pain and headache reports2025

A Promising Route for Established Indications: A Systematic Review of Nebulized Ketamine in Pain.

Neveen A Kohaf, Tabia Imtiyaz Khan, Hamada Hamdy Elbana, Ro'a Azzam Hassouna, Mohamed Maher Abd Elfattah, Prashant Nasa, Sahar Shekoohi, Alan David Kaye, Islam Mohammad Shehata

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neveen A KohafClinical Pharmacy Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-0369-6176
Tabia Imtiyaz KhanFaculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0009-0009-3646-9816
Hamada Hamdy ElbanaModern University for Technology & Information, Cairo, Egypt.ORCID https://orcid.org/0009-0004-6036-3564
Ro'a Azzam HassounaModern University for Technology & Information, Cairo, Egypt.
Mohamed Maher Abd ElfattahAnesthesia Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-6096-6294
Prashant NasaCritical Care Medicine NMC Specialty Hospital, Al Nahada 2, Dubai, United Arab Emirates.ORCID https://orcid.org/0000-0003-1948-4060
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA. sahar.shekoohi@lsuhs.edu.ORCID https://orcid.org/0009-0007-4545-4523
Alan David KayeDepartments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.ORCID https://orcid.org/0000-0003-2464-0187
Islam Mohammad ShehataAnesthesia Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-3663-3056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNebulized ketamine, an innovative route of drug delivery, has gained interest for its potential effectiveness in challenging clinical scenarios. The objective of this systematic review is to provide insights into the safety and effectiveness of nebulized ketamine in pain management.

methodA systematic search was performed on online databases including WOS, Cochrane, Scopus, and PubMed, using a specific search strategy. Our review focused on primary studies about the utilization of nebulized ketamine in various contexts regarding pain management. Additionally, we incorporated relevant secondary research, such as reviews presenting diverse perspectives.

resultsNebulized ketamine in pain management included nine studies.

conclusionThe advantages of nebulized ketamine over other forms of administration include its rapid absorption and effective delivery. The smaller volume required for nebulization can result in fewer side effects and enhanced patient compliance thereby facilitating efficient drug delivery while minimizing the systematic impact. Emerging evidence supports the administration of nebulized ketamine as a safe and efficacious treatment for acute pain. However, further investigations are needed for a better understanding of its pharmacokinetics, optimal dosing and efficacy across different populations.

Indexed as

AnalgesicsKetaminePainPain ManagementAdministration, InhalationHumansNebulizers and VaporizersAnalgesicsKetamineICUNebulized ketaminePainTrauma

Identifiers

PMID40304824

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.