ArticleDiscover oncology2025
The causal association between ankylosing spondylitis and endometrial cancer: a two-sample mendelian randomization study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
introductionMultiple studies suggest a link between ankylosing spondylitis (AS) and endometrial cancer (EC), but causality is uncertain.
methodWe used genome-wide association studies (GWAS) data in a Mendelian randomization analysis, primarily inverse variance weighting, to investigate if genetically determined AS affects EC risk, with sensitivity analyses for heterogeneity and pleiotropy.
resultsThe IVW results showed a possible causal association between AS and EC (non-endometrioid histology) (OR = 1.05, 95% CI 1.01-1.1, P = 0.02), while there was no significant association between AS and the risks of EC (endometrioid histology) (OR = 0.99, 95% CI 0.97-1.01, P = 0.35) with EC (OR = 0.99, 95% CI 0.98-1.01, P = 0.34). The analysis results of MR Egger, weighted median, simple mode and weighted mode for AS and EC (non-endometrioid histology) were insignificant. No statistically significant heterogeneity or horizontal pleiotropy was detected.
conclusionsThis MR analysis did not reveal a substantial association between AS and overall EC or EC of endometrioid histology. Conversely, a significant causal connection between AS and non-endometrioid histology EC was identified. Additional research to are needed to explore the mechanisms of the relationship between AS and EC with the non-endometrioid subtype.
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