Evidence map›Paper›PMID 40304801›Full record

Observational studyLangenbeck's archives of surgery2025

Does transanal total mesorectal excision (taTME) result in better quality of life and functional outcomes than traditional TME does? A retrospective propensity score-adjusted cohort study.

Yanic Ammann, Marie Klein, Lukas Marti, Rene Warschkow, Lennard Ströse, Moritz Sparn, Tarkan Jäger, Stephan Bischofberger, Walter Brunner

Registry-linked trialAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06505863 (Does Transanal Total Mesorectal Excision), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06505863 completednot on this map

Does Transanal Total Mesorectal Excision (taTME) Result in Better Quality of Life and Functional Outcomes Than Traditional Total Mesorectal Excision? A Retrospective Propensity Score-adjusted Cohort Study

TypeobservationalSponsorCantonal Hospital of St. GallenRan2024 to 2025Enrolled249ConditionsRectal Cancer, Quality of Life, Functional Outcome, SurgeryArmsTransanal total mesorectal excision, Abdominal total mesorectal excision
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanic Ammann *Department of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland. yanic.ammann@h-och.ch.ORCID https://orcid.org/0000-0001-5262-5449
Marie Klein *Department of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland.ORCID https://orcid.org/0009-0006-1491-8172
Lukas MartiDepartment of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland.ORCID https://orcid.org/0000-0001-5413-132X
Rene WarschkowDepartment of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland.ORCID https://orcid.org/0000-0001-9635-5751
Lennard StröseDepartment of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland.ORCID https://orcid.org/0009-0000-3179-1448
Moritz SparnDepartment of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland.ORCID https://orcid.org/0000-0002-5908-5454
Tarkan JägerDepartment of Surgery, Paracelsus Medical University Salzburg, Salzburg, Austria.ORCID https://orcid.org/0000-0002-2390-0226
Stephan BischofbergerDepartment of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland.ORCID https://orcid.org/0009-0009-8434-679X
Walter BrunnerDepartment of General, Visceral, Endocrine and Transplant Surgery, Cantonal Hospital of St.Gallen, Rorschacherstrasse 95, St.Gallen, CH-9007, Switzerland.ORCID https://orcid.org/0000-0002-4344-3093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe improved prognosis of rectal cancer through modern therapeutic approaches raises questions regarding quality of life (QoL) and functional outcomes. In this study, we compared post-transanal total mesorectal excision (taTME) short- and long-term QoL and functional outcomes with those after abdominal TME (abTME).

methodsProspective data from patients who underwent elective taTME or abTME for stage I-III rectal cancer followed by anastomosis were retrospectively propensity score-adjusted. The primary endpoint, QoL, was assessed with the European Organization for Research and Treatment of Cancer core questionnaire (EORTC QLQ-C30). Functional outcomes were the secondary endpoints.

resultsAmong 494 patients during 2013-2022, 187 patients who underwent taTME and 62 patients who underwent abTME were included. QoL was worse after taTME at isolated time points: overall QoL (after 3 years: 72 vs. 82 points, p = 0.017) and QLQ-total (after 3 years: 81 vs. 87 points, p = 0.028; after 4 years: 82 vs. 89 points, p = 0.012). After propensity score matching, the between-group differences were still significant but smaller: overall QoL - 6 points, p = 0.021; QLQ-total - 5 points, p = 0.026.

conclusionThe differences reported at isolated time points have questionable clinical relevance. Therefore, taTME and traditional abTME seem to have comparable long-term QoL and functional outcomes. CLINICAL

trial registrationClinicalTrials.gov, NCT06505863, https://clinicaltrials.gov/search?id=NCT06505863 .

Indexed as

ProctectomyQuality of LifeRectal NeoplasmsTransanal Endoscopic SurgeryAgedFemaleHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesTreatment OutcomeFunctional outcomeLaparoscopic total mesorectal excisionQuality of lifeRectal cancerTransanal total mesorectal excision

Identifiers

PMID40304801
PMCPMC12043741

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.