Evidence map›Paper›PMID 40304783›Full record

ArticleClinical oral investigations2025

Characterization and effects on enamel of low-concentration bleaching gels containing hyaluronic acid, NF_TiO

Marcos Roberto Lima Benati, Matheus Kury, Priscila Borges Gobbo de Melo, Iago César Ribeiro Teles Matos, Roberta Tarkany Basting, Rosanna Tarkany Basting, Fernando Luis Esteban Florez, Vanessa Cavalli

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marcos Roberto Lima BenatiDepartment of Restorative Dentistry, University of Campinas- Piracicaba Dental School (FOP- UNICAMP), Piracicaba, SP, Brazil.
Matheus KuryGraduate Program in Dentistry, Paulista University (UNIP), São Paulo, SP, Brazil.
Priscila Borges Gobbo de MeloDepartment of Restorative Dentistry, University of Campinas- Piracicaba Dental School (FOP- UNICAMP), Piracicaba, SP, Brazil.
Iago César Ribeiro Teles MatosDepartment of Restorative Dentistry, University of Campinas- Piracicaba Dental School (FOP- UNICAMP), Piracicaba, SP, Brazil.
Roberta Tarkany BastingDepartment of Restorative Dentistry, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
Rosanna Tarkany BastingLaboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
Fernando Luis Esteban FlorezDepartment of Restorative Sciences, University of Oklahoma - Health Sciences Center, Oklahoma City, OK, USA.
Vanessa CavalliDepartment of Restorative Dentistry, University of Campinas- Piracicaba Dental School (FOP- UNICAMP), Piracicaba, SP, Brazil. cavalli@unicamp.br.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior- Brazil (CAPES) Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo, Brasil 2022/04618-8
6 · The paper itself

Abstract

objectiveTo characterize and evaluate experimental in-office bleaching gels containing hyaluronic acid (HA) or carbomer 940 (CAR), enriched with NF_TiO₂ nanoparticles and irradiated with a violet LED, assessing their effects on the physicochemical properties of enamel. MATERIALS AND

methodsBovine enamel-dentin discs were treated according to the parameters: thickener (HA or CAR), HP concentration (1.5% or 6%), and irradiation (with or without LED), resulting in 9 experimental groups (n = 10/group). An additional control group (35%HP-commercial) was adopted, and three sessions were conducted (30 min each, with a 7-day interval). Gels were evaluated for pH, particle size, polydispersity index, zeta potential and rheological behavior. Samples were assessed for color change (ΔE

resultspH remained stable above 6.0. Hyaluronic-based gels exhibited higher particle size and polydispersity, but lower zeta potential and less viscous rheological behavior compared to the carbomer-based ones (p < 0.05). LED light significantly increased ΔE

conclusionExperimental hyaluronic or carbomer bleaching gels incorporated with NF_TiO CLINICAL RELEVANCE: Innovative bleaching gel formulations incorporating hyaluronic acid, NF_TiO₂ nanoparticles, and violet LED light irradiation exhibit high efficacy even at low hydrogen peroxide concentrations, thereby minimizing enamel damage and potentially mitigating post-operative sensitivity.

Indexed as

Dental EnamelHyaluronic AcidNanoparticlesTitaniumTooth BleachingTooth Bleaching AgentsAcrylic ResinsAnimalsCattleGelsHydrogen-Ion ConcentrationIn Vitro TechniquesLightMicroscopy, Electron, ScanningParticle SizeRheologyAcrylic Resinscarbopol 940GelsHyaluronic AcidTitaniumtitanium dioxideTooth Bleaching AgentsDental bleachingHyaluronic acidHydrogen peroxideNanotechnology

Identifiers

PMID40304783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.