Evidence map›Paper›PMID 40304782›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

PSMA PET/CT in biochemical recurrence of prostate cancer with PSA levels ≤ 0.2 ng/mL: a German multicenter analysis of conventional PSMA tracers, including [

Caroline Burgard, Madita Frei, Arne Blickle, Philipp E Hartrampf, Manuela A Hoffmann, Mathias Schreckenberger, Hans-Peter Schmid, Lena Unterrainer, Julian Rogasch, Markus Galler and 2 more

Abstract readMulticenter Study
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Diagnostic Value of Routine Delayed Pelvic Imaging for Patients with Biochemical Recurrence of Prostate Cancer UndergoingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Caroline BurgardDepartment of Nuclear Medicine, Saarland University- Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.
Madita FreiDepartment of Nuclear Medicine, Saarland University- Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.
Arne BlickleDepartment of Nuclear Medicine, Saarland University- Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.
Philipp E HartrampfDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Manuela A HoffmannDepartment of Nuclear Medicine, Johannes Gutenberg University- Medical Center, Mainz, Germany.
Mathias SchreckenbergerDepartment of Nuclear Medicine, Johannes Gutenberg University- Medical Center, Mainz, Germany.
Hans-Peter SchmidDepartment of Nuclear Medicine, Ludwig Maximilian University of Munich- University Hospital, Munich, Germany.
Lena UnterrainerDepartment of Nuclear Medicine, Ludwig Maximilian University of Munich- University Hospital, Munich, Germany.
Julian RogaschCharité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Markus GallerCharité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Samer EzziddinDepartment of Nuclear Medicine, Saarland University- Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany.
Florian RosarDepartment of Nuclear Medicine, Saarland University- Medical Center, Kirrberger Str. 100, Geb. 50, D-66421, Homburg, Germany. florian.rosar@uks.eu.ORCID 0000-0002-2985-4099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate-specific membrane antigen (PSMA)-directed positron emission tomography/computed tomography (PET/CT) has emerged as a highly accurate imaging modality for detecting tumor lesions in patients with biochemical recurrence (BCR) of prostate cancer (PC). While detection rates of lesions suspicious for PC relapse are known to increase with rising prostate-specific antigen (PSA) levels, data on the efficacy of PSMA PET/CT at very low PSA values (≤ 0.2 ng/mL) remain limited.

methodsIn this multicenter study, we analyzed 321 patients with BCR and a PSA value ≤ 0.2 ng/mL across five German academic centers, using three different PSMA-targeted radiotracers: [

resultsThe overall pooled detection rate was 29.6%. No statistically significant differences in detection rates were observed between the three radiotracers ([

conclusionAll three radiotracers demonstrated comparable diagnostic performance, with no significant superiority observed between the

Indexed as

Antigens, SurfaceEdetic AcidGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingOligopeptidesPositron Emission Tomography Computed TomographyProstate-Specific AntigenProstatic NeoplasmsAgedAged, 80 and overFluorine RadioisotopesGallium IsotopesGallium RadioisotopesGermanyHumansMaleAntigens, SurfaceEdetic AcidFluorine RadioisotopesFOLH1 protein, humangallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingNiacinamideOligopeptidesProstate-Specific AntigenPSMA-1007PSMA-11Radioactive TracersRadiopharmaceuticalsBiochemical recurrenceDetection ratePET/CTPSAPSMAPSMA-1007PSMA-11PSMA I&T

Identifiers

PMID40304782
PMCPMC12491085

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.