Evidence map›Paper›PMID 40304760›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Acute kidney injury with cast nephropathy following creatine loading in a 17-year-old.

Guido Filler, Eugene Maung, Maria Esther Díaz González de Ferris, Nancy Gain Chan, Ajay Parkash Sharma

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Creatine supplementation and the young kidney.Nature reviews. Nephrology · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guido FillerChildren's Health Research Institute, Western University, London, ON, N6 C 2 V5, Canada. guido.filler@lhsc.on.ca.ORCID 0000-0003-1891-6765
Eugene MaungDepartment of Pediatrics, Western University Schulich School of Medicine & Dentistry, London, ON, N6 A 5 W9, Canada.ORCID 0009-0004-2315-1466
Maria Esther Díaz González de FerrisDepartment of Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, N5 A 5 A5, Canada.ORCID 0000-0003-1694-886X
Nancy Gain ChanLilibeth Caberto Kidney Clinical Research Unit, London Health Sciences Centre; and Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, N6 A 5 W9, Canada.
Ajay Parkash SharmaDepartment of Pediatrics, Western University Schulich School of Medicine & Dentistry, London, ON, N6 A 5 W9, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case highlights a 17-year-old male who developed acute kidney injury (AKI) with cast nephropathy following a 6-day high-dose creatine loading regimen. The patient presented with bilateral flank pain, a parallel rise in cystatin C and creatinine, and kidney enlargement on ultrasound despite adequate hydration and the absence of rhabdomyolysis markers. Renal biopsy confirmed cast nephropathy without evidence of light chain disease. This case underscores the potential risks of high-dose creatine use in adolescents and highlights the importance of kidney function monitoring in athletes using sports supplements.

Indexed as

Acute Kidney InjuryCreatineDietary SupplementsAdolescentBiopsyCreatinineHumansKidneyMaleCreatineCreatinineAcute kidney injuryCast nephropathyCreatineCystatin CPediatric renal diseaseSports supplements

Identifiers

PMID40304760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.