Evidence map›Paper›PMID 40304749›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Analgesic and neuroprotective effect of a lipid transfer protein isolated from Morinda citrifolia L. (noni) seeds on oxaliplatin-induced peripheral sensory neuropathy in mice.

Francisco Rafael Alves Santana Cesário, Jonas Costa de França, Anamaria Falcão Pereira, Diego Bernardo Souza Dias, Amanda Rocha de Oliveira, Andrea Santos Costa, Ana Paula Negreiros Nunes Alves, Nylane Maria Nunes de Alencar, Hermógenes David de Oliveira, Mariana Lima Vale

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Combined intervention ofFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francisco Rafael Alves Santana CesárioDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Jonas Costa de FrançaDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Anamaria Falcão PereiraDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Diego Bernardo Souza DiasDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Amanda Rocha de OliveiraDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Andrea Santos CostaDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici Prof. Prisco Bezerra, Fortaleza, CE, Brazil.
Ana Paula Negreiros Nunes AlvesFaculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, CE, Brazil.
Nylane Maria Nunes de AlencarDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Hermógenes David de OliveiraDepartment of Biochemistry and Molecular Biology, Federal University of Ceará, Campus do Pici Prof. Prisco Bezerra, Fortaleza, CE, Brazil.
Mariana Lima ValeDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil. marianavale@ufc.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Process PR2-0101-00054.01.00/15Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP) Process PR2-0101-00054.01.00/15
6 · The paper itself

Abstract

Oxaliplatin, a 3rd-generation platinum compound, has a dose-limiting effect: neurotoxicity manifests as peripheral sensory neuropathy (PNS). Many studies have assessed the different pharmacological properties of a lipid transfer protein isolated from Morinda citrifolia L. (McLTP

Indexed as

AnalgesicsMorindaNeuroprotective AgentsOxaliplatinPeripheral Nervous System DiseasesActivating Transcription Factor 3AnimalsDisease Models, AnimalGanglia, SpinalHyperalgesiaMaleMiceSciatic NerveSeedsSpinal CordTRPA1 Cation ChannelActivating Transcription Factor 3AnalgesicsNeuroprotective AgentsOxaliplatinTRPA1 Cation ChannelTrpa1 protein, mouseTRPM8 protein, mouseTRPM Cation ChannelsLipid transfer proteinMorinda citrifolia L.OxaliplatinPeripheral neuropathyTRPM8

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.