Trial reportIntensive care medicine2025
Low versus high positive end expiratory pressure in noninvasive ventilation for hypoxemic respiratory failure: a multicenter randomized controlled trial.
Trial report in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Balancing lung recruitment and venous congestion in ARDS: rethinking the systemic effects of PEEP.Intensive care medicine · 2026Article
- Update on acute respiratory failure.Intensive care medicine · 2026Article
- The association of arterial partial oxygen pressure with mortality in patients with severe acute pancreatitis: a retrospective cohort study.Intensive care medicine experimental · 2025Article
- A clinical guide to non-invasive respiratory support in acute respiratory failure: ventilation settings, technical optimization and clinical indications.Critical care (London, England) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
purposeTo assess whether high positive end expiratory pressure (PEEP) reduces the rate of noninvasive ventilation (NIV) failure in hypoxemic patients.
methodsThis multicenter, open-label, randomized controlled trial was conducted across seven ICUs in China. Hypoxemic patients who received NIV via oronasal or nasal mask were randomized 1:1 to either low PEEP (5 cmH
resultsBetween January 11, 2022, and August 31, 2024, 380 patients (190 per group) were enrolled in an intention-to-treat analysis. NIV failure occurred in 43% (82/190) of the low PEEP group and 32% (61/190) of the high PEEP group (absolute difference: 11.1%, 95% CI 1.3-20.5%, p = 0.034). Within 72 h post-randomization, the low PEEP group exhibited lower PaO
conclusionsHigh PEEP during NIV may reduce treatment failure in patients with acute hypoxemic respiratory failure, although this benefit may be partially confounded by higher tidal volume observed in the low PEEP group. However, the interpretation of this effect should be carried out with caution as the study has insufficient statistical power to detect a significant difference.
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Registered trials
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