ArticleeLife2025
Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Inter-regional interactions uncouple within-region inhibition stabilization and paradoxical responses.bioRxiv : the preprint server for biology · 2026Article
- Multi-stable oscillations in cortical networks with two classes of inhibition.PLoS computational biology · 2026Article
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- Characteristics and dynamical signatures of recurrent cortical circuits during context-dependent processing.bioRxiv : the preprint server for biology · 2026Article
- Sexually dimorphic plasticity of PV inhibition in sensory neocortex during learning.Scientific reports · 2026Article
- Task success in trained spiking neural network models coincides with emergence of cross-stimulus-modulated inhibition.Biological cybernetics · 2026Article
- Delayed integration of somatostatin interneurons into visual circuits.Nature communications · 2025Article
- State modulation in spatial networks with three interneuron subtypes.Science advances · 2025Article
- Extending Mathematical Frameworks to Investigate Neuronal Dynamics in the Presence of Microglial Ensheathment.Bulletin of mathematical biology · 2025Article
- Parvalbumin interneurons: the dark and bright sides of a key playmaker of neural circuits and behavior.Frontiers in cellular neuroscience · 2025Review
- Dynamical mechanisms of how an RNN keeps a beat, uncovered with a low-dimensional reduced model.Scientific reports · 2024Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The mechanics of correlated variability in segregated cortical excitatory subnetworks.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Top-down modulation in canonical cortical circuits with short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Emergence of co-tuning in inhibitory neurons as a network phenomenon mediated by randomness, correlations, and homeostatic plasticity.Science advances · 2024Article
- Emergence of Emotion Selectivity in Deep Neural Networks Trained to Recognize Visual Objects.bioRxiv : the preprint server for biology · 2024Article
- Emergence of Emotion Selectivity in Deep Neural Networks Trained to Recognize Visual Objects.PLoS computational biology · 2024Article
- Excitation creates a distributed pattern of cortical suppression due to varied recurrent input.Neuron · 2023Article
- Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage.Nature communications · 2023Article
- The mechanics of correlated variability in segregated cortical excitatory subnetworks.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
4 authors.
Funding
Abstract
Synaptic inhibition is the mechanistic backbone of a suite of cortical functions, not the least of which are maintaining network stability and modulating neuronal gain. In cortical models with a single inhibitory neuron class, network stabilization and gain control work in opposition to one another - meaning high gain coincides with low stability and vice versa. It is now clear that cortical inhibition is diverse, with molecularly distinguished cell classes having distinct positions within the cortical circuit. We analyze circuit models with pyramidal neurons (E) as well as parvalbumin (PV) and somatostatin (SOM) expressing interneurons. We show how, in E - PV - SOM recurrently connected networks, SOM-mediated modulation can lead to simultaneous increases in neuronal gain and network stability. Our work exposes how the impact of a modulation mediated by SOM neurons depends critically on circuit connectivity and the network state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.