Evidence map›Paper›PMID 40304522›Full record

ReviewEcoSal Plus2025

The EcoCyc database (2025).

Peter D Karp, Suzanne Paley, Ron Caspi, Anamika Kothari, Markus Krummenacker, Peter E Midford, Lisa R Moore, Pallavi Subhraveti, Socorro Gama-Castro, Víctor H Tierrafria and 13 more

Abstract readReview
In one paragraph

Review in EcoSal Plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Comparative Characterization of σInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
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  14. Proteome-wide analysis of protein stability in Escherichia coli under acid stress.Journal of industrial microbiology & biotechnology · 2026
    Article
  15. Article
  16. Article
  17. Using CRISPRi inJournal of microbiology & biology education · 2025
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Peter D KarpBioinformatics Research Group, SRI International, Menlo Park, California, USA.ORCID 0000-0002-5876-6418
Suzanne PaleyBioinformatics Research Group, SRI International, Menlo Park, California, USA.ORCID 0000-0001-5763-8935
Ron CaspiBioinformatics Research Group, SRI International, Menlo Park, California, USA.
Anamika KothariBioinformatics Research Group, SRI International, Menlo Park, California, USA.
Markus KrummenackerBioinformatics Research Group, SRI International, Menlo Park, California, USA.
Peter E MidfordBioinformatics Research Group, SRI International, Menlo Park, California, USA.
Lisa R MooreBioinformatics Research Group, SRI International, Menlo Park, California, USA.
Pallavi SubhravetiBioinformatics Research Group, SRI International, Menlo Park, California, USA.
Socorro Gama-CastroPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Víctor H TierrafriaPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Paloma LaraPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Luis Muñiz-RascadoPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
César Bonavides-MartinezPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Alberto Santos-ZavaletaPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Amanda MackieSchool of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Gwanggyu SunDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Travis A Ahn-HorstDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Heejo ChoiDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Riley JuenemannDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Cyrus N M KnudsenDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Markus W CovertDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Julio Collado-VidesPrograma de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Ian PaulsenSchool of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0001-9015-9418

Funding

The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
Development and Support of the Pathway Tools SoftwareR01AI160719 · NIAID · SRI INTERNATIONAL · PI PETER D KARP · 2021 to 2026
$5.9M
The EcoCyc Model Organism Database for Escherichia coliR01GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2019 to 2022
$4.6M
The BioCyc, MetaCyc, and EcoCyc Knowledge BasesR24GM150703 · NIGMS · SRI INTERNATIONAL · PI PETER D KARP · 2023 to 2026
$4.6M
Deep Curation via an Integrated Whole-Cell Computational ModelR01LM013229 · NLM · STANFORD UNIVERSITY · PI COVERT, MARKUS W · 2020 to 2023
$1.5M
NIAID NIH HHS R01 AI160719NIGMS NIH HHS R01 GM077678NIGMS NIH HHS R24 GM150703NIGMS NIH HHS U24 GM077678NIH HHS 1R24GM150703NLM NIH HHS R01 LM013229
6 · The paper itself

Abstract

EcoCyc is a bioinformatics database (DB) available at EcoCyc.org that describes the genome and the biochemical machinery of

Indexed as

Databases, GeneticEscherichia coli K12Genome, BacterialComputational BiologyEscherichia coliGene Expression Regulation, BacterialMetabolic Networks and PathwaysOperonSoftwarebioinformaticsdatabaseEscherichia coli

Identifiers

PMID40304522
PMCPMC12707148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.