Evidence map›Paper›PMID 40304512›Full record

ArticleJournal of bacteriology2025

Azithromycin represses evolution of ceftazidime/avibactam resistance by translational repression of

Congjuan Xu, Jie Feng, Yuchen Zhou, Huan Ren, Xiaolei Pan, Shuiping Chen, Xuehua Liu, Guanxian Li, Jinjin Li, Bin Geng and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Distinctive Lacritin Cleavage-Potentiated Bactericidal Alteration of thebioRxiv : the preprint server for biology · 2026
    Article
  2. Hypermucoviscosity inJournal of bacteriology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Congjuan XuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Jie FengState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Yuchen ZhouState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Huan RenState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Xiaolei PanState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.ORCID 0000-0003-0907-2177
Shuiping ChenDepartment of Infection and Control, 5th Medical Center of PLA General Hospital, Beijing, China.
Xuehua LiuTianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
Guanxian LiTianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
Jinjin LiTianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
Bin GengTianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
Linlin GaoTianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
Zhihui ChengState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Yongxin JinState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.ORCID 0000-0002-1449-6735
Un-Hwan HaDepartment of Biotechnology and Bioinformatics, Korea University, Sejong, South Korea.ORCID 0000-0001-9182-7000
Shouguang JinState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Iain L LamontDepartment of Biochemistry, University of Otago, Dunedin, Otago, New Zealand.ORCID 0000-0002-7601-6354
Daniel PletzerDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-5750-7505
Weihui WuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.ORCID 0000-0002-9017-0091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic combinations can slow down resistance development and/or achieve synergistic therapeutic effects. In this study, we observed that a combined use of ceftazidime-avibactam (CZA) with azithromycin effectively repressed CZA resistance development in

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsAzithromycinBacterial ProteinsCeftazidimePseudomonas aeruginosaSigma FactorAnimalsDrug CombinationsDrug Resistance, Multiple, BacterialGene Expression Regulation, BacterialMiceMicrobial Sensitivity TestsProtein BiosynthesisPseudomonas InfectionsAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsAzithromycinBacterial ProteinsCeftazidimeDrug CombinationsSigma Factorsigma factor KatF protein, Bacteriaantibiotic combinationceftazidime-avibactamPseudomonas aeruginosa

Identifiers

PMID40304512
PMCPMC12096824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.