Evidence map›Paper›PMID 40304491›Full record

ArticleJournal of virology2025

Dendritic cell expression of MyD88 is required for rotavirus-induced B cell activation.

Sarah E Blutt, Amber D Miller, Margaret E Conner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah E BluttDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-4062-709X
Amber D MillerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Margaret E ConnerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-7146-8159

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
SUBUNIT ROTAVIRUS VACCINES &MUCOSAL IMMUNITYR01AI024998 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CONNER, MARGARET E. · 1987 to 2013
$4.0M
Immune Mechansims of Rotavirus Protection &ClearanceF32AI010604 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BLUTT, SARAH E · 2001 to 2002
$86k
SUBUNIT ROTAVIRUS VACCINES AND MUCOSAL IMMUNITYR21AI024998 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CONNER, MARGARET E. · 1999 to 1999
–
NIAID NIH HHS F32 AI010604NIAID NIH HHS R01 AI024998NIAID NIH HHS R21 AI024998NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Intestinal IgA, produced by local intestinal B cells, is thought to play a major role in protection against intestinal infections. Rotavirus, a well-characterized intestinal virus, induces a rapid viral-specific intestinal IgA response that occurs in the absence of T cells. Previous work has indicated that dendritic cells facilitate the early IgA response to rotavirus. To determine whether the early Peyer's patch B cell activation associated with rotavirus infection in mice requires dendritic cells, we depleted dendritic cells and assessed B cell activation. Depletion of CD11c

Indexed as

B-LymphocytesDendritic CellsLymphocyte ActivationMyeloid Differentiation Factor 88RotavirusRotavirus InfectionsAnimalsCD11c AntigenImmunoglobulin AMiceMice, Inbred C57BLPeyer's PatchesSignal TransductionCD11c AntigenImmunoglobulin AMyd88 protein, mouseMyeloid Differentiation Factor 88B celldendritic cellMyD88rotavirus

Identifiers

PMID40304491
PMCPMC12090804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.