Evidence map›Paper›PMID 40304412›Full record

ArticleCNS neuroscience & therapeutics2025

miR-484 in Hippocampal Astrocytes of Aged and Young Rats Targets CSF-1 to Regulate Neural Progenitor/Stem Cell Proliferation and Differentiation Into Neurons.

Jiahua Qu, Zhichao Lu, Yongbo Cheng, Song Deng, Wei Shi, Qianqian Liu, Yuejuan Ling

Abstract readInteractive Tutorial
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiahua QuResearch Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Zhichao LuResearch Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Yongbo ChengResearch Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Song DengResearch Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Wei ShiResearch Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Qianqian LiuResearch Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Yuejuan LingResearch Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.ORCID 0009-0006-6524-4948

Funding

National Key Research and Development Program of China 2023YFC2306502National Natural Science Foundation of China 82301561National Natural Science Foundation of China 82371398Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX24_3626
6 · The paper itself

Abstract

aimAging-related cognitive decline is closely linked to the reduced function of neural progenitor/stem cells (NPSCs), which can be influenced by the neural microenvironment, particularly astrocytes. The aim of this study was to explore how astrocytes affect NPSCs and cognitive function during aging.

methodsH

resultsHigh concentration of CSF-1 inhibited the NPSC proliferation and differentiation into neurons while inducing apoptosis. Overexpression of miR-484 downregulated CSF-1 expression by binding to its 3' untranslated region, thereby promoting the NPSC proliferation and differentiation into neurons. In 20-month-old rats, miR-484 overexpression improved spatial learning and memory in the Morris water maze, increased NPSC proliferation, and reduced apoptosis.

conclusionOur findings reveal that miR-484 regulates CSF-1 to influence NPSC proliferation, differentiation into neurons, and apoptosis, consequently improving cognitive function in 20-month-old rats. This study provides a foundation for developing therapeutic strategies targeting age-related hippocampal cognitive impairments.

Indexed as

AgingAstrocytesCell DifferentiationCell ProliferationHippocampusMacrophage Colony-Stimulating FactorMicroRNAsNeural Stem CellsNeuronsAnimalsCells, CulturedMaleRatsRats, Sprague-DawleyMacrophage Colony-Stimulating FactorMicroRNAsagingastrocytesCSF‐1miR‐484neural progenitor/stem cells

Identifiers

PMID40304412
PMCPMC12042212

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.