Evidence map›Paper›PMID 40304342›Full record

ArticleCombinatorial chemistry & high throughput screening2025

Exploring Potential Bifunctional Peptides with Anti-tyrosinase and Antioxidant Activities from

Si-Bo Huang, Pei-Xia Feng, Liu-Ying Li, Hong-Hui Guo, En-Qin Xia

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Article in Combinatorial chemistry & high throughput screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Si-Bo HuangSchool of Public Health, Shunde Women and Child's Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China.ORCID 0009-0003-0741-2067
Pei-Xia FengSchool of Public Health, Shunde Women and Child's Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China.
Liu-Ying LiSchool of Public Health, Shunde Women and Child's Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China.
Hong-Hui GuoSchool of Public Health, Shunde Women and Child's Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China.
En-Qin XiaSchool of Public Health, Shunde Women and Child's Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China.

Funding

Honghui Guo Ph.D; Medical Fund Project of Guangdong Province A2023434Special Fund for Key Areas of Universities in Guangdong Province 2024ZDZX2071
6 · The paper itself

Abstract

backgroundExtracts from Porphyra have been detected to have antioxidant activity and tyrosinase (TYR) inhibitory activity. However, bioactive peptides (BPs) released from Porphyra proteins (PPs) have not been comprehensively reported.

objectiveThe aim of this study is to rapidly identify bifunctional peptides with antioxidant and TYR inhibitory activities from a large number of digested peptides from PPs.

methodsIn this study, a total of 3,288 proteins from six main species of Porphyra were collected, and the antioxidant potential (AP) was evaluated. Hydrolyzed peptides with 2-8 amino acid lengths were collected and known antioxidants were removed. Next, these peptides were further screened using ADMET analysis. Finally, the DPPH· scavenging potential (IC

resultsThe most released antioxidant peptides after digestion of all types of PPs were dipeptides with sequences EL, IR and AY. In addition, 44,689 short non-repeatable peptides were swirled in these hydrolysates, which have not yet been reported to have antioxidant activity. Next, 337 of these digested peptides were predicted to be absorbed without hepato-renal toxicity and had virtual metabolic scores > 0.01%. Finally, 138 peptides were predicted to have AP and TIP.

conclusionPorphyra is a kind of promising source rich in bifunctional peptides. Present study adopted an innovative method with some free scripts to rapid discovery of bifunctional peptides from a large number of unknown PPs.

Indexed as

AntioxidantsEnzyme InhibitorsMonophenol MonooxygenasePeptidesPorphyraBiphenyl CompoundsComputer SimulationMolecular Docking SimulationPicratesQuantitative Structure-Activity Relationship1,1-diphenyl-2-picrylhydrazylAntioxidantsBiphenyl CompoundsEnzyme InhibitorsMonophenol MonooxygenasePeptidesPicratesAMDETbioactive peptidesbioinformaticsin silicopharmacophore.Porphyra proteinsQSAR

Identifiers

PMID40304342

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.