Evidence map›Paper›PMID 40304321›Full record

ReviewCurrent radiopharmaceuticals2025

RNA Binding Proteins are Pivotal Regulators of Cancer Radioresistance and Potential Targets for Preventing Tumor Recurrence.

Vasanth Kanth Thasma LoganathBabu, Srisri Satishkartik, Vanshikaa Karthikeyan, Sayantani Chattopadhyay, Shriya P, Harin N Ganesh, Kirubakaran Rangasamy, Satish Ramalingam, ArulJothi Kandasamy Nagarajan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current radiopharmaceuticals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vasanth Kanth Thasma LoganathBabuDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.
Srisri SatishkartikDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.
Vanshikaa KarthikeyanDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.
Sayantani ChattopadhyayDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.
Shriya PDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.
Harin N GaneshDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.
Kirubakaran RangasamyDepartment of Biotechnology, Vinayaka Missions Kirupananda Variyar Engineering College, Vinayaka Missions Research Foundation, Salem, Tamilnadu, 636308, India.
Satish RamalingamDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.
ArulJothi Kandasamy NagarajanDepartment of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu, Chennai, Tamilnadu, 603203, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA-binding proteins (RBPs) regulate gene expression at the post-transcriptional level and are important factors in cancer progression and response to various therapeutic strategies. Radioresistance, an obstacle caused due to various intrinsic and extrinsic factors, remains a major hindrance in the treatment of cancer and could lead to tumor recurrence. Though research is being conducted on the cause and association of radioresistance with various cellular and environmental factors, there remains much to be explored and discovered. The roles of several RNA-binding proteins in tumor progression and metastasis are well documented. In addition, recent studies suggest the connection between Cancer Stem Cells (CSCs) and chemoresistance. We and others have extensively studied the regulatory role of RBPs in regulating CSCs. Resistance to radiation therapy and the involvement of RBPs in this process is under-studied. In this review, we have provided an updated compilation of the significant role played by RBPs in radioresistance.

Indexed as

Neoplasm Recurrence, LocalNeoplasmsRadiation ToleranceRNA-Binding ProteinsAnimalsGene Expression Regulation, NeoplasticHumansNeoplastic Stem CellsRNA-Binding Proteinscancercancer stem cellscancer therapeuticsgenesradioresistanceradiotherapyRNA-binding proteinstranscription factors.

Identifiers

PMID40304321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.