Evidence map›Paper›PMID 40304280›Full record

ArticleClinical and experimental dental research2025

Histological Evaluation of Subcutaneous Tissue Reactions to a Novel Bilayer Polycaprolactone/Silk Fibroin/Strontium Carbonate Nanofibrous Membrane for Guided Bone Regeneration: A Study in Rabbits.

Lida Kheiri, Arash Golestaneh, Mehdi Mehdikhani, Sayed Mohammad Razavi, Niloofar Etemadi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Harnessing strontium in regenerative dentistry: progress and perspectives.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lida KheiriDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran.ORCID 0000-0001-9471-9902
Arash GolestanehDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran.
Mehdi MehdikhaniDepartment of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.
Sayed Mohammad RazaviDepartment of Oral and Maxillofacial Pathology, Dental Implants Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Niloofar EtemadiDepartment of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

objectivesThe selection of appropriate biomaterial for guided bone regeneration is challenging. The blending of polymers is a simple method to retain their characteristics and to compensate for the drawbacks of each component. The release of Sr MATERIAL AND

methodsEighteen male New Zealand rabbits were randomly divided into three groups, and all received subcutaneously the following materials: novel bilayer membrane, commercial membrane, and empty defect as control group, which were tested after 7, 14, and 28 days. The type and severity of inflammation, granulation tissue, and fibrous tissue were assessed.

resultsThe connective tissue surrounding the implanted samples of each group exhibited the presence of similar cells close to the control groups. Statistical analyses showed no significant differences between the specimens in each time period.

conclusionsIn general, the novel bilayer nanocomposite membrane was a biocompatible material and produces a similar subcutaneous response compared to commercially available membrane. Besides, it demonstrated promise for guided bone regeneration technique for treating the osseous defects of oral and maxillofacial region.

Indexed as

Bone RegenerationFibroinsGuided Tissue RegenerationMembranes, ArtificialNanofibersPolyestersStrontiumSubcutaneous TissueAnimalsBiocompatible MaterialsMaleRabbitsBiocompatible MaterialsFibroinsMembranes, ArtificialpolycaprolactonePolyestersStrontiumbilayer membranepolycaprolactonesilk fibroinstrontium carbonate

Identifiers

PMID40304280
PMCPMC12042107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.