Evidence map›Paper›PMID 40304242›Full record

ArticleBiochemistry2025

Targeting Apicomplexan Parasites: Structural and Functional Characterization of

Federica Gabriele, Jala A Bogard, Marta Palerma, Matteo Ardini, Margaret E Byrne, Xian-Ming Chen, Pavel A Petukhov, Rodolfo Ippoliti, Francesco Angelucci, David L Williams

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Federica GabrieleDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.
Jala A BogardDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois 60612, United States.ORCID 0009-0007-7920-1292
Marta PalermaDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.ORCID 0009-0001-8404-6828
Matteo ArdiniDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.ORCID 0000-0002-9044-3352
Margaret E ByrneDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois 60612, United States.
Xian-Ming ChenDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois 60612, United States.ORCID 0000-0001-9848-2244
Pavel A PetukhovDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0003-1554-242X
Rodolfo IppolitiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.
Francesco AngelucciDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.ORCID 0000-0001-7305-7903
David L WilliamsDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois 60612, United States.ORCID 0000-0002-6815-4909

Funding

Development of novel TGR inhibitors for the treatment of schistosomiasisR01AI177493 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Pavel A Petukhov, DAVID LEE WILLIAMS · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI177493
6 · The paper itself

Abstract

Cryptosporidiosis poses a significant health threat to young children and immunocompromised individuals due to the lack of effective therapies. Here, we demonstrate that the

Indexed as

CryptosporidiumCryptosporidium parvumProtozoan ProteinsThioredoxin-Disulfide ReductaseAuranofinCryptosporidiosisCrystallography, X-RayGlutathioneHumansModels, MolecularOxidation-ReductionThioredoxinsAuranofinGlutathioneProtozoan ProteinsThioredoxin-Disulfide ReductaseThioredoxins

Identifiers

PMID40304242
PMCPMC12092171

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.