Evidence map›Paper›PMID 40304057›Full record

ArticleMovement disorders clinical practice2025

Tics and Parkinson's Disease: Clinical and Pathophysiological Insights from a Rare Syndromic Association.

Tarig Abkur, Alexandra Boogers, Talyta Grippe, David A Isaacs, Irene A Malaty, Renato P Munhoz, Kailash P Bhatia, Lauren A Hart, Alfonso Fasano, Suneil Kalia and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tarig Abkur *Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Alexandra Boogers *Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-5427-0781
Talyta GrippeEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
David A IsaacsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-9860-1052
Irene A MalatyDepartment of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0001-6914-9223
Renato P MunhozEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Kailash P BhatiaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0001-8185-286X
Lauren A HartCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Alfonso FasanoEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-5346-0180
Suneil KaliaKrembil Research Institute, Toronto, Ontario, Canada.
Anthony E LangEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Christos GanosEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

Funding

Neurophysiologic Correlates of Sensory Over-Responsivity in Tourette SyndromeK23NS131592 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David A Isaacs · 2023 to 2026
$707k
NINDS NIH HHS K23 NS131592
6 · The paper itself

Abstract

backgroundThe coexistence of tics with Parkinson's disease (PD) is rare, as they often emerge at different ages, follow different trajectories and involve contrasting pathophysiological mechanisms related to dopamine availability and function in the brain. CASES: We present 10 individuals with primary tic disorders who later developed PD. Tic severity remained unchanged with the onset of parkinsonism or dopaminergic treatment. Peak-dose dyskinesias in two cases did not affect tics, and deep brain stimulation of the subthalamic nucleus transiently induced tics in one individual with PD.

conclusionsThe evidence drawn from this case series does not support a linear relation between nigrostriatal dopaminergic availability and tics. It suggests that tics may instead arise from a more complex interplay between multiple neurotransmitter systems acting on several networks within the cortico-striatal-thalamic circuits.

Indexed as

Parkinson DiseaseTic DisordersTicsDeep Brain StimulationHumansNeurotransmittersparkinsonismParkinson's diseaseTicsTourette's syndrome

Identifiers

PMID40304057
PMCPMC12371469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.