ArticleFrontiers in oncology2025
The TFRC as a prognostic biomarker and potential therapeutic target in cervical cancer: a preliminary study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Transferrin receptor 1: an emerging therapeutic target in cancer beyond iron metabolism.Cancer cell international · 2026Review
- Review
- What If Trojan Horse Nanoparticles Could Change the Game for HPV Gene-Targeted Therapies?Journal of medical virology · 2026Review
- Iron and metabolic rewiring in cancer.Oncogenesis · 2026Review
- Autophagy modulation in gynaecologic oncology: insights into immune regulation and therapeutic potential.Frontiers in immunology · 2026Review
- Beyond Iron: The Roles of CD71 in the Pathophysiology of Cancer-A Comprehensive Review.Journal of clinical medicine · 2025Review
- Vitamins and minerals and their role in cancer: a comprehensive review.Frontiers in nutrition · 2025Review
- Identification and validation of ubiquitination-related genes for predicting cervical cancer outcome.Frontiers in genetics · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: Early detection and treatment of CIN or early-stage cervical cancer lead to better clinical outcomes compared to treating advanced-stage patients. Thus, specific biomarkers for the diagnosis and prognosis of CIN and early-stage cervical cancer should be urgently explored. Methods: We analyzed tumor based on genes closely related to OS in the database with GSE63514, GSE7803, GSE9750 and TCGA data sets, the top 20 core genes were screened out. Notably, transferrin receptor (TFRC) emerged as a prioritized candidate due to its dual role in cellular iron homeostasis and oncogenic signaling. However, the exact role of TFRC in the development and progression of cervical cancer remains unclear. We then used various bioinformatics methods and mathematical models to analyze those data, aiming to investigate the clinical significance of TFRC in cervical cancer and illustrate its association with tumor immunity. In addition, the molecular function and mechanisms of TFRC were revealed by gene ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment analysis. Immunohistochemistry was employed to assess TFRC protein expression in 19 cervical cancers, 16 HSILs and 15 normal cervical tissues. Results: TFRC was highly expressed in CESC in the TCGA and GSE9750 datasets. Meanwhile, the expression of TFRC was correlated with pathological stage, lymph node metastasis, malignant degree of cervical lesions and HPV infection status. Our analysis confirmed that TFRC expression was higher in CESC tissues compared to normal cervical tissues, and it was also elevated in HSIL relative to normal tissues, as determined by IHC staining. Increased TFRC expression was linked to decreased overall survival (OS) ( Conclusions: TFRC exhibits significant diagnostic and prognostic value in cervical cancer.
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