Evidence map›Paper›PMID 40303982›Full record

ArticleFrontiers in dental medicine2025

Investigating possible shared single nucleotide polymorphisms in isolated oral cleft and non-cleft facial morphology.

Erika Calvano Küchler, Michelle Nascimento Meger, Bruna Correia Rauta Pires, Svenja Beisel-Memmert, Daniel Hemming, Ricardo D Coletta, Rafaela Scariot, Mírian Aiko Nakane Matsumoto, Maria Angelica Hueb de Menezes Oliveira, Christian Kirschneck and 1 more

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Article in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Erika Calvano KüchlerDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany.
Michelle Nascimento MegerSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
Bruna Correia Rauta PiresSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
Svenja Beisel-MemmertDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany.
Daniel HemmingSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
Ricardo D ColettaDepartment of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil.
Rafaela ScariotDepartment of Stomatology, Federal University of Paraná, Curitiba, Paraná, Brazil.
Mírian Aiko Nakane MatsumotoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, USP-São Paulo University, Ribeirão Preto, São Paulo, Brazil.
Maria Angelica Hueb de Menezes OliveiraDepartment of Biomaterials, University of Uberaba, Uberaba, Minas Gerais, Brazil.
Christian KirschneckDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany.
Bianca Cavalcante-LeãoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Facial morphogenesis is regulated by several cellular interactions that are mediated by numerous morphogenetic signals. Based on the existing evidence, we hypothesize that oral cleft-associated single nucleotide polymorphisms (SNPs) are involved in the normal range of human face development. Therefore, this study aimed to investigate the association between SNPs in oral cleft-related genes and variations in the normal range of facial morphology. Method: A sample of healthy Brazilian teenagers (aged between 11 and 18 years old) were screened and collected. Frontal facial digitized photographs from orthodontic records were used to determine phenotypes, while the DNA extracted from saliva samples was used to investigate the candidate SNPs. Five oral cleft-associated SNPs in Results: A total of 58 individuals (27 boys and 31 girls) were included. The facial landmarks used for the facial measurements were the trichion (Tr), glabella (G), nassion (N), subnasale (Sn), labrale superior (Ls), labrale inferior (Li), gnathion (Gn), cheilon (Ch), and zygoma (Zg). Conclusion: Our study supported the hypothesis that oral cleft-associated SNPs are involved in the normal range of human facial morphology.

Indexed as

cleft lip and/or palatecraniofacial developmentfacegenespolymorphism

Identifiers

PMID40303982
PMCPMC12037601

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