ArticleFrontiers in genetics2025
Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: While genome-wide association studies (GWAS) have identified numerous susceptibility loci in Colorectal cancer (CRC), most findings are based on European populations. Additionally, CRC shares genetic architecture with other traits, and multi-trait analysis can improve the discovery of pleiotropic loci. Materials and methods: We conducted a multi-trait GWAS using the Multi-Trait Analysis of GWAS (MTAG) framework, leveraging large-scale genomic and phenotypic data from BioBank Japan (BBJ). We also examined genetic correlations between CRC and 70 complex traits, followed by local genetic correlation analysis and enrichment of heritability partitioned by chromatin states and tissue types. Results: We identified 25 genome-wide significant loci for CRC and colon polyps, including three novel loci in East Asian populations: Conclusion: Our study identifies novel pleiotropic loci associated with CRC in East Asians, emphasizing the importance of population-specific genetic studies. The findings provide new insights into the genetic architecture of CRC and its shared pathways with other complex diseases.
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