ArticleHealth science reports2025
No Bidirectional Causal Relationship Between Traumatic Brain Injury and Parkinson's Disease: A Two-Sample Mendelian Randomization Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Insomnia-Driven Hippocampal Atrophy: Evidence From Bidirectional Mendelian Randomization.Health science reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The incidence of Parkinson's disease (PD) is significantly increased in older people who have experienced traumatic brain injury (TBI), suggesting that TBI may be a potential risk factor for PD. However, the causal relationship remains ambiguous. Objective: To investigate the association between TBI and PD using Mendelian randomization (MR) analyses. Methods: Four genome-wide association databases were reviewed in detail, including GWAS Catalog, FinnGen, IEU OpenGWAS, and UK Biobank. Genetic data for TBI were obtained from the FinnGen data set, including 7430 clinically diagnosed cases and 404,751 controls, and PD was obtained from a meta-analysis in the GWAS Catalog, including 42,792 cases and 568,693 controls. The bidirectional two-sample MR analyses were used to investigate the causal association between TBI and PD. Results: There was no evidence of a causal relationship between TBI and an increased risk of PD (IVW; OR = 1.11; 95% CI, 0.91-1.36; Conclusions: No causal relationship was found between TBI and PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.