Evidence map›Paper›PMID 40303901›Full record

ArticlePain reports2025

Adverse childhood experiences and multisite pain among adolescents in the United States.

Tristin Smith, Dorna Kheirabadi, Yijun Guo, Junzhi Sun, Jennifer Pierce, Rachel S Bergmans, Kevin F Boehnke, Andrew Schrepf, Daniel Clauw, Chelsea M Kaplan and 1 more

Abstract read
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In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Beyond pain presence: the impact of multisite pain and pain interference on cognitive functioning among middle-aged and older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tristin SmithDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Dorna KheirabadiDepartment of Anesthesiology, Henry Ford Hospital, Detroit, MI, USA.ORCID https://orcid.org/0000-0001-6366-8575
Yijun GuoDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Junzhi SunDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Jennifer PierceDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Rachel S BergmansDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kevin F BoehnkeDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrew SchrepfDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Daniel ClauwDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Chelsea M KaplanDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Anne ArewasikpornDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0003-4586-9124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Childhood adversity can have a lasting negative impact throughout one's life. Youth with pain conditions consistently report a higher rate of adverse childhood experiences (ACEs) when compared with their healthy peers. Adolescents experiencing pain in more than 1 region tend to have greater symptom burden and reduced quality of life. Research on the association between ACEs and multisite pain in adolescents is sparse. Objectives: The objective of our study was to investigate the association between cumulative ACEs and self-report of multisite pain in early adolescence using data from the Adolescent Brain Cognitive Development study. Methods: We used a 19-region body map to evaluate the presence of regional pain (1-2 regions) and multisite pain (≥3 regions). We analyzed data using multinominal logistic regression, adjusting for sociodemographic factors including pubertal status, sex, race/ethnicity, and income-to-needs ratio. Results: We included a total of 7582 children aged 12 to 13 years, with 33.4%, 24.0%, 13.2%, and 8.6% reporting 1, 2, 3, and 4+ ACEs, respectively. Moreover, 30.7%, 24.2%, 15.2%, and 10.1% of children with multisite pain reported 1, 2, 3, and 4+ ACEs, respectively. Those with 4+ ACEs (adjusted odds ratio 1.62, 95% confidence interval 1.24-2.12) and 3 ACEs (adjusted odds ratio 1.44, 95% confidence interval 1.14-1.82) were more likely to report multisite pain compared with the children with no ACEs. Conclusion: We showed a potential dose-response relationship between cumulative ACEs and multisite pain, suggesting that the impact of ACEs on pain, particularly multisite pain, may emerge earlier than previously documented.

Identifiers

PMID40303901
PMCPMC12040063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.