ArticleFrontiers in neurology2025
Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Patients with subthreshold depression (sD) carry a significant risk of developing major depressive disorder. However, few studies focus on the influence of Internet-based Cognitive Behavioral Therapy (ICBT) on brain network, particularly among Chinese undergraduates. This study aims to conduct resting-state functional MRI (rs-fMRI) to explore the effects of ICBT on neurofunctional network. Methods: This short-term longitudinal study enrolled 30 sD patients and 24 healthy matched participants. We gathered the clinical measurements outcomes from sD patients. Baseline and post-intervention MRI scans were performed for the sD patients, additionally, a matched healthy controls group underwent baseline MRI scans, functional network matrix was established from the temporal rs-MRI series. Nodal efficiency ( Results: The patients with sD exhibited reduced clinical measurement scores after ICBT intervention. Moreover, after ICBT intervention, functional network analysis revealed an increased Conclusion: This study showed alterations in brain network in patients with sD after ICBT intervention. These findings shed light on the neurofunctional mechanisms underlying the effects of ICBT in sD patients.
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