Gossypol Affects Viral Replication by Inhibiting Pseudorabies Virus Adsorption.

Yilin Bai, Bingqian Su, Xuan Cheng, Qianwen Liu, Lei Zeng, Pengfei Fu

Abstract read

In one paragraph

Article in Transboundary and emerging diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yilin BaiLaboratory of Indigenous Cattle Germplasm Innovation, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450046, Henan, China.

Bingqian SuCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China.

Xuan ChengCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China.

Qianwen LiuCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan 467044, Henan, China.

Lei ZengCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China.ORCID https://orcid.org/0000-0002-2470-7073

Pengfei FuCollege of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan 467044, Henan, China.ORCID https://orcid.org/0009-0004-2963-8056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudorabies virus (PRV) has spread widely in swine herds since it was introduced into China, and PRV variants have appeared in many regions in China since 2011. Owing to the ongoing emergence of viral mutations, the protective efficacy of PRV vaccines faces great challenges. Gossypol is a polyphenolic natural compound purified from cotton roots, stems, or seeds. This study found that gossypol has a notable inhibitory effect on PRV. Based on the biological effects of gossypol, the anti-PRV effect of gossypol was studied from the aspects of mitochondrial damage, reactive oxygen species, energy metabolism, and autophagy. The results showed that gossypol had no direct inactivation effect on PRV in solution within concentrations of ≤3

Indexed as

Antiviral AgentsGossypolHerpesvirus 1, SuidVirus ReplicationAnimalsAutophagyPseudorabiesReactive Oxygen SpeciesSwineAntiviral AgentsGossypolReactive Oxygen Species

Identifiers

PMID40303819

DOI10.1155/2023/9073566

PMCPMC12017124

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.