ArticleTransboundary and emerging diseases2023
Characterization of the First Case of Classical Scrapie in a Sheep in Tunisia.
Article in Transboundary and emerging diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Camel Prion Disease, Tataouine, Tunisia, 2019-2021.Emerging infectious diseases · 2026Article
- Whole-genome resequencing of the Kazakh coarse-wool fat-tailed sheep identifies functional variants in disease-associated genes.Frontiers in veterinary science · 2026Article
- Epidemiological landscape and genetic prospects for marker-assisted selection in Kazakh sheep.Frontiers in veterinary science · 2025Review
- Immunohistochemical study of scrapie in naturally affected sheep in the east of Libya.Open veterinary journal · 2024Article
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Authors and funding
24 authors.
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Abstract
Classical scrapie is a contagious prion disease of sheep and goats. It is endemic in many countries in Europe, North America, and Asia. In Africa, imported scrapie cases have been described in South Africa and Kenia in the past. More recently, several cases have been reported from different regions of Libya, based on clinical signs and histological lesions. Here, we report the results of thorough investigations carried out on a suspect case of scrapie in a 6-year-old Barbarine sheep, born, and bred in Tunisia, showing behavioral changes, weight loss, itching, skin lesions, wool loss, and motor incoordination. Histopathology and immunohistochemistry revealed spongiform change in several brain areas with associated pathological prion protein deposition. Western blotting confirmed the diagnosis and showed a classical scrapie-like molecular pattern of PrP
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