Evidence map›Paper›PMID 40303777›Full record

ArticleTransboundary and emerging diseases2023

Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022.

Luca De Sabato, Giovanni Ianiro, Giovanni L Alborali, Annelies Kroneman, Sylvia S Grierson, Gergana Lyubomirova Krumova-Valcheva, Renate W Hakze-van der Honing, Reimar Johne, Ivana Kolackova, Iwona Kozyra and 10 more

Abstract read
In one paragraph

Article in Transboundary and emerging diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Luca De SabatoDepartment Food Safety, Nutrition and Veterinary public Health, Istituto Superiore di Sanità, Rome, Italy.
Giovanni IaniroDepartment Food Safety, Nutrition and Veterinary public Health, Istituto Superiore di Sanità, Rome, Italy.ORCID https://orcid.org/0000-0002-8053-4904
Giovanni L AlboraliIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna "Bruno Ubertini", Brescia, Italy.
Annelies KronemanCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Sylvia S GriersonAnimal and Plant Health Agency, Weybridge, Addlestone, UK.
Gergana Lyubomirova Krumova-ValchevaNational Diagnostic and Research Veterinary Medicine Institute, National Food Safety Centre, Sofia 1606, Bulgaria.ORCID https://orcid.org/0000-0003-2386-2888
Renate W Hakze-van der HoningWageningen University and Research, Houtribweg 39, 8221 RA, Lelystad, Netherlands.
Reimar JohneGerman Federal Institute for Risk Assessment, Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany.
Ivana KolackovaDepartment of Public Health, Masaryk University, Brno, Czech Republic.
Iwona KozyraDepartment of Food and Environmental Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100, Puławy, Poland.
Eva GyurovaNational Diagnostic and Research Veterinary Medicine Institute, National Food Safety Centre, Sofia 1606, Bulgaria.
Enrico PavoniIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna "Bruno Ubertini", Brescia, Italy.
Katharina ReispDivision for Animal Health, Austrian Agency for Health and Food Safety (AGES), Mödling, Austria.
Elena Lucia SassuDivision for Animal Health, Austrian Agency for Health and Food Safety (AGES), Mödling, Austria.
Katja Schilling-LoefflerGerman Federal Institute for Risk Assessment, Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany.
Richard Piers SmithAnimal and Plant Health Agency, Weybridge, Addlestone, UK.
Petra VasickovaLaboratory of Neurobiology and Pathological Physiology, Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Brno, Czech Republic.
Jacek ŻmudzkiDepartment of Swine Diseases, National Veterinary Research Institute, Al. Partyzantów 57, Puławy 24-100, Poland.
Artur RzeżutkaDepartment of Food and Environmental Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100, Puławy, Poland.
Ilaria Di BartoloDepartment Food Safety, Nutrition and Veterinary public Health, Istituto Superiore di Sanità, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In high-income countries, the hepatitis E virus (HEV) is considered an emerging threat causing autochthonous acute hepatitis in humans, with an increased number of reported cases over the last 10 years and related increased burden of chronic hepatitis in immunocompromised and transplant patients. Pigs are the main reservoir of the HEV-3 genotype, which is the most common in Europe, and can be transmitted to humans through the consumption of raw and undercooked pork products. Extensive sequencing revealed the existence of several HEV-3 subtypes in both humans and pigs, confirming a broad heterogeneity of the virus, with some subtypes, such as 3e, 3f, and 3c, which are predominant in Europe. In this study, 291 HEV sequences were obtained from pig feces sampled in more than 74 farms located in Austria, Bulgaria, Czech Republic, Germany, Italy, Poland, the United Kingdom, as well as an unknown number of farms in Netherlands. Of the 99 nonidentical sequences (99/291), 90 were assigned to seven established HEV-3 subtypes: 3a, 3c, 3e, 3f, 3g (here named 3g-like), 3i, and 3l (named 3l-like), already described in Europe, while nine sequences of HEV-3 could not be assigned to any existing subtype (here named 3

Indexed as

Hepatitis EHepatitis E virusSwine DiseasesAnimalsEuropeFecesGenotypePhylogenySwine

Identifiers

PMID40303777
PMCPMC12016832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.