Evidence map›Paper›PMID 40303764›Full record

ArticleTransboundary and emerging diseases2023

Epidemiological and Genetic Analysis of Foot-and-Mouth Disease Virus O/ME-SA/Ind-2001 in China between 2017 and 2021.

Xiangle Zhang, Weimin Ma, Fan Yang, Yamin Yang, Lv Lv, Jinyan Wu, Baohong Liu, Chaochao Shen, Yongjie Liu, Zixiang Zhu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiangle ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Weimin MaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Fan YangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Yamin YangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Lv LvState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Jinyan WuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Baohong LiuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.ORCID https://orcid.org/0000-0003-4240-2748
Chaochao ShenState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Yongjie LiuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Zixiang ZhuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Youjun ShangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Jianhong GuoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Xiangtao LiuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.
Haixue ZhengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.ORCID https://orcid.org/0000-0001-6850-1379
Jijun HeState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China.ORCID https://orcid.org/0009-0004-2273-7991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The O/ME-SA/Ind-2001 lineage of foot-and-mouth disease virus (FMDV) was introduced into China in 2017, which subsequently caused 19 outbreaks of foot-and-mouth disease (FMD) and emerged in 8 provinces in China between 2017 and 2021. It is the first time for WOAH/national reference laboratory for FMD (LVRI) to comprehensively summarize these 19 outbreaks of O/ME-SA/Ind-2001 for consecutive 5 years. Our study selected and conducted whole viral genome sequencing for 9 representative isolates and the VP1 sequences of the FMDV-positive samples collected between 2017 and 2021. Analyses of these gene sequences showed that all the field strains belonged to O/ME-SA/Ind-2001e. Phylogenetic analysis indicated that these viruses were closely related to those circulating in neighboring countries, and there were at least 3 different FMD viral clades (named cluster 1, cluster 2, and cluster 3) circulating during this period. Also, a gradually decreasing nucleotide identity was observed in newly emerging viruses year by year compared with the first isolate identified in 2017. These results suggest extensive movements and constant and rapid evolvement of the O/ME-SA/Ind-2001e sublineage. Besides, the neutralizing antigenic sites in the structural proteins for these O/ME-SA/Ind-2001e viruses were analyzed to predict the vaccine matching between these strains and the commercial vaccine strain O/BY/CHA/2010. The results showed that the VP1 epitope 135-144, highly associated with neutralizing antibody induction, was variable among these strains. The mutations in this region reflected a potential risk of challenging the current vaccine protection. Therefore, there is an urgent need to reinforce the importance of improved FMD surveillance and monitor the evolution of O/ME-SA/Ind-2001e, which will provide essential information for the FMD control program in China and Asia.

Indexed as

Cattle DiseasesFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusSwine DiseasesAnimalsCattleChinaDisease OutbreaksGenome, ViralPhylogenySwine

Identifiers

PMID40303764
PMCPMC12016701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.