ArticleTransboundary and emerging diseases2023
Phylogeny and Pathogenicity of Subtype XIIb NDVs from Francolins in Southwestern China and Effective Protection by an Inactivated Vaccine.
Article in Transboundary and emerging diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Analysis of Newcastle disease virus prevalence in wild birds reveals interhost transmission of genotype VI strains.Microbiology spectrum · 2024Article
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12 authors.
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Abstract
Most genotype XII newcastle disease viruses (NDVs) were isolated from poultry, chickens, or geese, with the exception of one subtype, XIIa NDV, which was isolated from a peacock. Here, two subtype XIIb NDVs, francolin/China/GX01/2017 and francolin/China/GX02/2017 (GX01 and GX02 hereafter), were isolated from francolins, which are resident birds in southern China. GX01 and GX02 were characterized as velogenic NDVs. Based on the weaker pathogenicity of these viruses in chickens, the amino acid sequences of seven proteins from genotype XII NDVs were compared, which revealed 17, 40, 15, 7, 32, 25, and 31 variations in the NP, P, M, F, HN, L, and V proteins, respectively, some of which could be responsible for this decreased pathogenicity. Epidemiological and phylogenetic analyses suggest that subtype XIIb NDVs have multiple transmission chains, and that resident birds may be involved in this process as intermediate hosts in which viruses keep evolving. Because of the increased pathogenicity of subtype XIIb NDVs, the protective efficacy of GX01 as an inactivated vaccine was evaluated and compared with that of two commercial inactivated vaccines in chickens. The results showed that the subtype XIIb NDVs could be candidate genotype-matched vaccine strains against genotype XII NDVs.
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