ArticleTransboundary and emerging diseases2023
Genomic Characterization and Pathogenicity of BJEU06-1-Like PRRSV-1 ZD-1 Isolated in China.
Article in Transboundary and emerging diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Characterization and pathogenicity of single-farm-isolated PRRSV 1 and PRRSV 2 strain in China.Virulence · 2026Article
- Genetic Diversity, Phylogenetic Lineages, and Antigenic Features of the PRRSV-1 GP5 Gene in China.Microorganisms · 2026Article
- Genetic evolutionary and pathogenicity analyses of a novel porcine reproductive and respiratory syndrome virus 1 strain SC202404 that emerged in Southwestern China.BMC veterinary research · 2026Article
- Nanobody-based bioPROTAC for viral protein degradation provides an antiviral strategy for porcine arterivirus.Journal of nanobiotechnology · 2026Article
- Isolation, Genomic Characterization and Pathogenicity of a European-Like PRRSV-1 Strain in Newborn Piglets from Southwestern China.Veterinary sciences · 2026Article
- Persistent Circulation of Pseudorabies Virus Variants in China: Genomic Features, Pathogenic Characteristics, and Cross-Protective Efficacy of Variant Strain Vaccines.Transboundary and emerging diseases · 2026Article
- Genetic and Pathogenic Characteristics of Novel PRRSV-1 Strain CH-JX-2504 and CH-SDTA-2506 in China.Transboundary and emerging diseases · 2026Article
- Article
- Isolation and Genomic Characterization of a Novel Porcine Reproductive and Respiratory Syndrome Virus 1 from Severely Diseased Piglets in China in 2024.Veterinary sciences · 2025Article
- Whole-Genomic Characterization of Two Different PRRSV-1 Strains Isolated From a Single Pig.Transboundary and emerging diseases · 2025Article
- Molecular Characterization and Pathogenicity of a Novel Recombinant NADC30-Like PRRSV Strain Isolated From Piglets Inducing Intestinal Inflammation, and Construction of Its Infectious Clone.Transboundary and emerging diseases · 2025Article
- Genetic evolution, epidemic trends, and recombination dynamics of PRRSV-1 in China.Frontiers in veterinary science · 2025Article
- Isolation and pathogenicity comparison of two novel natural recombinant porcine reproductive and respiratory syndrome viruses with different recombination patterns in Southwest China.Microbiology spectrum · 2024Article
- A chimeric porcine reproductive and respiratory syndrome virus 1 strain containing synthetic ORF2-6 genes can trigger T follicular helper cell and heterologous neutralizing antibody responses and confer enhanced cross-protection.Veterinary research · 2024Article
- Dissecting Genetic Diversity and Evolutionary Trends of Chinese PRRSV-1 Based on Whole-Genome Analysis.Transboundary and emerging diseases · 2024Article
- Comparing the molecular evolution and recombination patterns of predominant PRRSV-2 lineages co-circulating in China.Frontiers in microbiology · 2024Article
- Whole Genome Characterization and Pathogenicity of a SC2020-1-Like PRRSV-1 Strain Emerging in Southwest China.Transboundary and emerging diseases · 2024Article
- Recent Progress in Studies of Porcine Reproductive and Respiratory Syndrome Virus 1 in China.Viruses · 2023Review
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Authors and funding
18 authors.
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Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV)-1 and PRRSV-2 have long been cocirculating in China. To date, all PRRSV-1 strains in China have been classified as subtype 1. We investigated the prevalence of PRRSV-1 in several areas of China from 2016 to 2022 and found that BJEU06-1-like strains comprised the main epidemic branch of PRRSV-1. Pathogenicity data for this subgroup are currently lacking. In this study, the Chinese BJEU06-1-like PRRSV-1 strain ZD-1 was isolated from primary alveolar macrophages (PAMs). ZD-1 has undergone no recombination and has a 5-aa discontinuous deletion in the Nsp2 protein, similar to other BJEU06-1-like strains; additionally, ZD-1 has a 26 aa C-terminal truncation in the GP3 gene. Pathogenicity studies revealed that ZD-1 causes obvious clinical symptoms: prolonged fever; reduced body weight; alveolar epithelial proliferation and moderate alveolar diaphragm widening in the lungs; diffuse lymphocytic hyperplasia in the lymph nodes; high levels of viremia in the serum; and elevated viral loads in the lungs, lymph nodes, and tonsils. These results suggested that the BJEU06-1-like PRRSV-1 strain ZD-1 is moderately pathogenic to piglets. This is the first study to evaluate the pathogenicity of the BJEU06-1-like branch in China, enriching the understanding of PRRSV-1 in China.
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