Evidence map›Paper›PMID 40303632›Full record

ArticleFrontiers in endocrinology2025

Variant pubertal development in Prader-Willi syndrome: early and slow progression of pubarche with normal age at gonadarche.

Aneta Kodytková, Petra Dušátková, Shenali Anne Amaratunga, Stanislava Koloušková, Barbora Obermannová, Renata Pomahačová, Štěpánka Průhová, Marta Šnajderová, Zdeněk Šumník, Jiřina Zapletalová and 2 more

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aneta KodytkováDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Petra DušátkováDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Shenali Anne AmaratungaDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Stanislava KolouškováDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Barbora ObermannováDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Renata PomahačováDepartment of Pediatrics, Faculty of Medicine, Charles University and University Hospital Pilsen, Pilsen, Czechia.
Štěpánka PrůhováDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Marta ŠnajderováDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Zdeněk ŠumníkDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
Jiřina ZapletalováDepartment of Pediatrics, Faculty of Medicine, Palacky University and Olomouc University Hospital, Olomouc, Czechia.
Valerij SemjonovDepartment of Statistics, Motol University Hospital, Prague, Czechia.
Jan LeblDepartment of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Prader-Willi syndrome (PWS) is primarily caused by a paternal microdeletion of the 15q11-q13 region, maternal uniparental disomy (mUPD) or unbalanced translocations. The Methods: Age at pubarche, gonadarche, subsequent pubertal progression and bone age (BA) at gonadarche were investigated in 37 PWS patients (18 females) who already entered pubarche and/or gonadarche with median age 11.1 (95% CI: 6.4 - 18.8) years. All patients were re-tested to confirm genetic subtypes of PWS. The Results: Out of 37 subjects, 22 had microdeletion and 15 mUPD. Regardless of genetic subtypes and Conclusions: Children with PWS, regardless of the genetic subtype and/or

Indexed as

Prader-Willi SyndromePubertyAdolescentChildDisease ProgressionFemaleHumansMaleRibonucleoproteinsUbiquitin-Protein LigasesMKRN3 protein, humanRibonucleoproteinsUbiquitin-Protein Ligasesbone agegonadarcheMKRN3 genePrader-Willi syndrome pubertypubarchepuberty

Identifiers

PMID40303632
PMCPMC12037383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.