Evidence map›Paper›PMID 40303587›Full record

ArticleClinical and experimental hepatology2025

NADK as a molecular marker to distinguish between alcohol- and non-alcohol-associated liver cirrhosis: A pilot study.

Ki-Hoon Park, Seok-Hyung Kim, So-Woon Kim, Kiyong Na, Sunyoung Kim, Young-Il Choi, Hyung-Joo Chung, Junyang Jung, Na Young Jeong

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Article in Clinical and experimental hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ki-Hoon ParkDepartment of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, South Korea.
Seok-Hyung KimSarcopenia Total Solution Center, Wonkwang University, South Korea.
So-Woon KimDepartment of Pathology, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, South Korea.
Kiyong NaDepartment of Pathology, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, South Korea.
Sunyoung KimDepartment of Family Medicine, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, South Korea.
Young-Il ChoiDepartment of Surgery, College of Medicine, Kosin University, South Korea.
Hyung-Joo ChungDepartment of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, South Korea.
Junyang JungDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, South Korea.
Na Young JeongDepartment of Anatomy and Cell Biology, College of Medicine, Dong-A University, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of the study: We investigated whether nicotinamide adenine dinucleotide kinase (NADK) expression is selectively diminished in alcohol-associated liver cirrhosis (AC), and evaluated its potential as a biomarker for this condition. Material and methods: Human liver samples were obtained during liver transplantation or resection procedures at Kosin University Gospel Hospital and classified into two groups: AC and non-AC (NAC). NAD Results: LC-MS analysis indicated a significant reduction in NAD Conclusions: This study revealed a distinct decrease in NADK expression in AC, suggesting its utility as a molecular marker for diagnosing and understanding metabolic dysregulation in these patients. These findings provide a foundation for developing targeted therapeutic strategies for alcohol-associated liver cirrhosis.

Indexed as

alcoholic liver cirrhosisbiomarkermeta-analysisNAD kinase (NADK)nicotinamide-adenine dinucleotide (NAD)

Identifiers

PMID40303587
PMCPMC12035712

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