ArticleCureus2025
Long-Term Regenerative Potential of Submandibular Glands in Albino Rats Following Radiotherapy: Role of Cytokeratin 17 Redistribution.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Regenerative potential of the intermediate filaments of albino rat parotid glands subjected to fractionated radiotherapy: an immunohistochemical analysis.Acta odontologica Scandinavica · 2025Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFractionated radiotherapy (RT) is a common approach for treating head and neck malignancies in which the salivary glands become included within the radiation field, causing xerostomia. This study aimed to evaluate the long-term effects of post-dose RT to determine the possibility of recovery of the submandibular gland (SMG) without intervention or further deterioration.
methodsTwenty-seven albino rats were divided into three equal groups, each containing nine rats. The first group is the control group, which was not exposed to radiation. The second and third groups served as the experimental groups, receiving a total radiation dose of 30 Gy, divided into 5 Gy doses per day over six consecutive days. The SMGs were extracted and prepared for histopathological and immunohistochemical analysis, one month after irradiation for Group II and one year after irradiation for Group III.
resultsImmunohistochemical analysis of the control salivary gland revealed weak to mild staining for cytokeratin 17 (CK17) (intermediate filaments) in the cells of the duct system and serous acinar cells. The irradiated SMG exhibited significantly moderate to strong cytokeratin expressions in the duct cells (P=0.000 for Group II and P=0.025 for Group III) compared with the control. In contrast, the serous acinar cells in Group II exhibited significantly increased immunostaining for cellular keratin (P = 0.001) compared to the control group. Meanwhile, the acinar cells in Group III showed CK17 expression levels similar to those observed in the control group (P = 0.297).
conclusionCK17 expression differed significantly between the control and the second group, which underwent a one-month wait after the final radiation dose. In contrast, the third group, which underwent a one-year wait, showed intermediate results between the two groups, indicating a more advanced stage of recovery. Statistical analysis showed differing recovery dynamics, with ductal cells exhibiting slower recovery than acinar cells, which appeared more advanced in their healing. These findings highlight the progressive yet varied repair processes within the irradiated glands.
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