ArticleCureus2025
Elevated Oxytocin Levels and Their Relationship to Metabolic Syndrome and Obesity Among Young Sudanese Adults: A Cross-Sectional Analysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenome-wide association study meta-analysis of BMI in African Americans.HGG advances · 2026Pooled it
- Oxytocin, Weight Loss and Ketosis in Response to a Very-Low-Calorie Ketogenic Diet: An Exploratory Study.Nutrients · 2026Article
- The serum oxytocin correlated with serum leptin and body mass index in Japanese adolescents.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study was to determine the prevalence of metabolic syndrome (MetS) and obesity in young adults from Sudan, investigate their effect on plasma levels of oxytocin, and examine the association of oxytocin level with the determinants of metabolic syndrome and obesity.
methodsThis was a cross-sectional study that included 202 young adults. Random sampling was applied to recruit volunteers from Ribat University, Khartoum, Sudan. Blood pressure, waist circumference, and plasma lipids were measured and applied for the diagnosis of metabolic syndrome according to the National Cholesterol Education Program - Adult Treatment Panel III (NCEP ATP III) criteria. Fasting blood glucose and insulin were used to validate the insulin resistance in patients with MetS. Oxytocin was measured using enzyme-linked immunosorbent assay (ELISA).
resultsMetabolic syndrome was diagnosed in 29 students (14.36%). Mean oxytocin level was significantly higher in students with MetS (10.34 pg/mL, N=29) compared with students without MetS (9.15 pg/mL, N=174) (P < 0.001). Mean oxytocin level did not differ between students with homeostatic model assessment for insulin resistance (HOMA-IR) ≥ 2.5 (N=47), and without HOMA-IR < 2.5 (N=155); the oxytocin level was 9.53 pg/mL and 9.25 pg/mL, respectively (P = 0.068). Moderate positive correlations existed between oxytocin and waist circumference, BMI, body weight, triglycerides (TG), hip circumference, and high-density lipoprotein (HDL; P < 0.001). Oxytocin did not correlate with fasting blood glucose.
conclusionOxytocin levels increased in young adults with MetS. Oxytocin levels correlate positively with BMI, waist circumference, blood pressure, triglycerides, and HDL.
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