ArticleFrontiers in immunology2025
Obinutuzumab for treatment of membranous nephropathy in patients positive and negative for the phospholipase A
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Membranous nephropathy (MN) is a common cause of nephrotic syndrome (NS) in adults. Without treatment, two-thirds of patients with MN develop nonprogressive chronic kidney disease or end-stage renal disease within 10 years. Obinutuzumab (OBZ), which binds to CD20 and leads to a pronounced depletion of B cells, may elicit a better therapeutic response in patients with refractory MN who do not respond to rituximab or who have recurrent episodes. Methods: We describe two MN patients, one positive and one negative for the M-type phospholipase A Results: The patient positive for PLA Discussion: OBZ appears to be a suitable alternative when other treatment options are ineffective or contraindicated. The efficacy of OBZ for treatment of refractory MN needs to be verified by large-scale multicenter clinical trials.
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