ArticleFrontiers in immunology2025
Mechanical stress contributes to ligamentum flavum hypertrophy by inducing local inflammation and myofibroblast transition in the innovative surgical rabbit model.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Increased scleraxis expression is associated with ligamentum flavum hypertrophy in patients with lumbar spinal canal stenosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Prioritization of Candidate miRNA Regulators Targeting Fibrotic-Immune Remodeling in Ligamentum Flavum Hypertrophy: An Integrated mRNA-miRNA Transcriptomic Study.Biomedicines · 2026Article
- Fascia as a Functional System in Health and Disease: From Fundamental Biology to Assessment and Targeted Interventions.International journal of molecular sciences · 2026Review
- Laminectomy aloneWorld journal of orthopedics · 2026Review
- Electroacupuncture in non-surgical management of lumbar spinal stenosis: mechanistic potential in attenuating ligamentum flavum thickening via inflammatory factor modulation.Frontiers in immunology · 2025Review
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Authors and funding
5 authors.
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Abstract
Background: Lumbar spinal canal stenosis (LSCS) ranks as a prevalent spinal disorder in senior populations. Ligamentum flavum hypertrophy (LFH) is a significant feature of LSCS, yet its cause is unclear. The purpose of this study was to create a novel animal model for LFH and explore the pathological mechanisms involved. Methods: A novel rabbit model for intervertebral mechanical stress concentration was established through posterolateral fusion using steel wire. Radiological analysis and biological validation were used to determine the crucial role of mechanical stress in LFH and explore the effect of this animal model. Results: After 12 weeks, the LF subjected to mechanical stress concentration exhibited a disruption and reduction in elastic fibers, collagen accumulation, increased thickness of LF, elevated LF cells, and increased levels of certain factors related to fibrosis and inflammation. These findings were histologically consistent to those found in human LFH. Furthermore, Conclusion: This novel rabbit model is able to replicate the moderate pathological features of human LFH. Mechanical stress is an independent factor leading to LFH, which can promote the TGF-β1 secretion in LF cells and some inflammatory cells, subsequently induce the myofibroblast transition, and finally result in collagen accumulation and LF fibrosis.
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