Evidence map›Paper›PMID 40303396›Full record

ArticleFrontiers in immunology2025

Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag.

Antonella Sau, Gianfranco Di Prinzio, Daniela Onofrillo, Anna Caterina Russo, Nicole Santoro, Mauro Di Ianni

Abstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antonella SauDepartment of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy.
Gianfranco Di PrinzioDepartment of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy.
Daniela OnofrilloDepartment of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy.
Anna Caterina RussoDepartment of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy.
Nicole SantoroDepartment of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy.
Mauro Di IanniDepartment of Medicine and Sciences of Aging, G. d'Annunzio University of Chieti and Pescara, Chieti, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune thrombocytopenia (ITP) is a rare hematologic disorder characterized by low platelet counts due to an immune-mediated destruction of platelets. While corticosteroids, intravenous immunoglobulin (IVIG) are the mainstays of treatment, a subset of patients may remain refractory to these therapies. Here, we present a case of a 6-year-old girl diagnosed with refractory ITP, who failed to respond to standard therapies but showed a remarkable clinical improvement with avatrombopag, a thrombopoietin receptor agonist.

Indexed as

Purpura, Thrombocytopenic, IdiopathicReceptors, ThrombopoietinThiazolidinesThiophenesChildFemaleHumansThiazolesTreatment OutcomeavatrombopagReceptors, ThrombopoietinThiazolesThiazolidinesThiophenesavatrombopagchildrenimmune thrombocytopaenia (ITP)persistent or chronic immune thrombocytopeniaplateletthrombopoietin receptor (TPOr) agonists

Identifiers

PMID40303396
PMCPMC12037552

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.