Evidence map›Paper›PMID 40303351›Full record

ArticleTheranostics2025

Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis.

Hitomi Yagi, Chenxi Qiu, Yan Zeng, Myriam Boeck, Shen Nian, Chuck T Chen, Jarrod C Harman, Taku Kasai, Jeff Lee, Victoria Hirst and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Macular telangiectasia type 2: An update.The Journal of international medical research · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hitomi YagiDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chenxi QiuDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Yan ZengDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Myriam BoeckDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Shen NianDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chuck T ChenDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Jarrod C HarmanDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Taku KasaiCenter for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jeff LeeDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Victoria HirstDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Katherine NeilsenDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chaomei WangDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kiran BoraDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Meenakshi MauryaDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Tori RodrickMetabolomics Core Resource Laboratory, NYU Langone Health, New York, NY 10016, USA.
Matthew GrumbineEnTox Sciences, Inc., Mercer Island, WA 98040, USA.
Yuelin YangDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Zhanqing HuaDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ian R SweetUniversity of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA 98109, USA.
Sasha A SinghCenter for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Masanori AikawaCenter for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jing ChenDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Zhongjie FuDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Dietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8M
RORalpha mediates chronic subretinal inflammation associated with AMDR01EY024963 · NEI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, JING · 2015 to 2025
$4.2M
Regulation of RPE degeneration by REV-ERBalphaR01EY031765 · NEI · BOSTON CHILDREN'S HOSPITAL · PI JING CHEN · 2020 to 2026
$2.7M
Wnt signaling-mediated control of blood-retinal barrierR01EY028100 · NEI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, JING · 2017 to 2021
$2.2M
Serine control of retinal neovascularization in retinopathyR01EY032492 · NEI · BOSTON CHILDREN'S HOSPITAL · PI FU, ZHONGJIE · 2021 to 2025
$2.2M
NEI NIH HHS R01 EY017017NEI NIH HHS R01 EY024963NEI NIH HHS R01 EY028100NEI NIH HHS R01 EY031765NEI NIH HHS R01 EY032492NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HypoxiaRetinal NeovascularizationSerineAngiogenesisAnimalsAnimals, NewbornDietary SupplementsDisease Models, AnimalFemaleMiceMice, Inbred C57BLMitochondriaOxidative PhosphorylationOxygenRetinaRetinopathy of PrematurityOxygenSerineangiogenesisneovascularizationretinaretinopathy of prematurityserine

Identifiers

PMID40303351
PMCPMC12036884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.