ArticleInternational journal of biological sciences2025
A Novel Mouse Model of Depression: Advantages in Immune Research and Clinical Translation.
Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Immunotherapy for depression: targeting cytokine pathways in major depressive disorder.Psychopharmacology · 2026Review
- Mechanism-Driven Translation of Electroacupuncture for Depression: Bridging the Gap Between Preclinical and Clinical Research.Neuropsychiatric disease and treatment · 2026Review
- TAAR1 deficiency impairs mitochondrial dynamics and synaptic integrity in the medial prefrontal cortex and associated cognition in mice.Translational psychiatry · 2025Article
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7 authors.
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Abstract
The role of neuroimmune mechanisms in major depressive disorder (MDD) has been gradually highlighted, but existing classical animal models of MDD have limitations in immune inflammation research due to physical injury, high mortality rates, and immune tolerance. This study developed a novel mouse model of depression called the post-witness social defeat stress (PWSDS) model, which combines witness stress with the social defeat paradigm. The model was evaluated based on behavior, central and peripheral immune responses, and predictive validity. The findings revealed that PWSDS-exposed mice exhibited significant anxiety-like behavior, depressive-like behavior, cognitive deficits, and enhanced peripheral and central neuroimmune responses. Additionally, the antidepressant fluoxetine effectively ameliorated the depressive-like phenotypes and immune response in stressed mice. The model captured certain aspects of the behavioral and peripheral immune features of MDD patients. The levels of cortisol and proinflammatory cytokines such as TNFα in the serum of MDD patients with adult stressors increased compared with healthy controls, and were alleviated by SSRIs treatment, accompanied by improvement in depressive symptoms, anxiety symptoms and cognitive impairments. This study establishes an improved mouse model of MDD, which has specific advantages in immune research and offers a novel approach to further study the pathogenesis and new treatment of MDD.
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