Evidence map›Paper›PMID 40303286›Full record

ArticleInternational journal of biological sciences2025

Antitumor Effects of Sesamin via the LincRNA-p21/STAT3 Axis in Human Bladder Cancer: Inhibition of Metastatic Progression and Enhanced Chemosensitivity.

Chao-Yen Ho, Thomas I-Sheng Hwang, Pei-Wen Peng, Te-Fu Tsai, Kuang-Yu Chou, Hung-En Chen, Peng-Hui Chang, Wei-Chien Huang, Chung-Hua Hsu, Tsai-Ju Chien and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chao-Yen HoInstitute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan, R.O.C.
Thomas I-Sheng HwangDivision of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan, R.O.C.
Pei-Wen PengSchool of Dental Technology, Taipei Medical University, Taipei 110301, Taiwan, R.O.C.
Te-Fu TsaiInstitute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan, R.O.C.
Kuang-Yu ChouInstitute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan, R.O.C.
Hung-En ChenInstitute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan, R.O.C.
Peng-Hui ChangDepartment of Urology, Wuri Lin Shin Hospital, Taichung 41454, Taiwan, R.O.C.
Wei-Chien HuangGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan, R.O.C.
Chung-Hua HsuInstitute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan, R.O.C.
Tsai-Ju ChienInstitute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan, R.O.C.
An-Chen ChangTranslational Medicine Center, Research Department, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC) ranks as the tenth most common malignancy worldwide, with high recurrence and progression rates despite current treatments. The matrix metalloproteinases (MMPs), particularly MMP2, play critical roles in tumor invasion and metastasis, contributing to poor prognosis. The p53-induced long noncoding RNA (lncRNA) lincRNA-p21, which acts as a tumor suppressor, has been implicated in various cancers, but its role in BC remains unclear. Sesamin, a bioactive lignan derived from sesame oil, has shown promise as a chemopreventive agent with multiple antitumor effects. In this study, sesamin was found to significantly inhibit cell viability

Indexed as

Antineoplastic AgentsDioxolesLignansRNA, Long NoncodingSTAT3 Transcription FactorUrinary Bladder NeoplasmsAnimalsCell Line, TumorCell MovementCell SurvivalHumansMatrix Metalloproteinase 2MiceMice, Inbred BALB CMice, NudeSignal TransductionAntineoplastic AgentsDioxolesLignansMatrix Metalloproteinase 2RNA, Long NoncodingsesaminSTAT3 protein, humanSTAT3 Transcription Factorbladder cancerchemosensitivityLincRNA-p21MMP2sesamin

Identifiers

PMID40303286
PMCPMC12035904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.