ArticleTransboundary and emerging diseases2024
Characterization and Pathogenicity of the Novel Porcine Reproductive and Respiratory Syndrome Virus 1 Strain SL-01 in China.
Article in Transboundary and emerging diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Characterization and pathogenicity of single-farm-isolated PRRSV 1 and PRRSV 2 strain in China.Virulence · 2026Article
- Genetic and Pathogenic Characteristics of Novel PRRSV-1 Strain CH-JX-2504 and CH-SDTA-2506 in China.Transboundary and emerging diseases · 2026Article
- Isolation and Genomic Characterization of a Novel Porcine Reproductive and Respiratory Syndrome Virus 1 from Severely Diseased Piglets in China in 2024.Veterinary sciences · 2025Article
- The DEAD-box RNA helicase 27 negatively regulates the replication of porcine reproductive and respiratory syndrome virus by mediating GP2a autophagy degradation and inducing interferon-β production.Frontiers in immunology · 2025Article
- Isolation and pathogenicity of the novel porcine reproductive and respiratory syndrome virus 1 strain ZJ01 in South China.Frontiers in cellular and infection microbiology · 2025Article
- Whole-Genomic Characterization of Two Different PRRSV-1 Strains Isolated From a Single Pig.Transboundary and emerging diseases · 2025Article
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11 authors.
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Abstract
Currently, PRRSV-1 causes a large number of clinical infections in Chinese swine herds, and the prevalence of new strains has presented great challenges. In this study, the novel PRRSV-1 strain SL-01 was isolated, with a genome length of 14,978 bp, and genetic evolution analysis revealed that it belonged to a new subtype branch. Sequence homology analysis showed that the strain was only 82.2%-86.7% identical to the current classical PRRSV-1 strains. In particular, the novel strain exhibited a unique deletion pattern in Nsp2. In addition, GP3 and GP4 of the SL-01 strain showed four consecutive amino acid deletions in the highly variable regions at amino acids 243-248 and 63-68, respectively. Further challenges in piglet and pregnant sow demonstrated that the SL-01 strain could cause the piglet fever and death but less pathogenic to pregnant sow. Overall, the characterization and pathogenicity of a novel PRRSV-1 strain were first explored and provide a prevention for pig farms.
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