ArticleTransboundary and emerging diseases2024
Isolation and Pathogenicity of a Chinese Porcine Astrovirus Type 5 Strain HNPDS-01 and Its Influence on Cecum Microbiota in Piglets.
Article in Transboundary and emerging diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Genome-wide CRISPR screening identifies Annexin A1 as a facilitator of porcine astrovirus entry.PLoS pathogens · 2026Article
- Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein.Virologica Sinica · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astroviruses have frequently been found in mammals and poultry, but only a few have been successfully isolated for extensive research. Here, we isolated a strain of porcine astrovirus type 5 (PAstV 5) on LLC-porcine kidney (LLC-PK) cells, from the intestinal contents of diarrhea piglets, namely PAstV 5-HNPDS-01. The complete genome sequence length of this strain was 6,419 nt, which has 77.2%-91.1% nucleotide homology with other PAstV 5 strains and 45.0%-50.0% nucleotide homology with other mammalian astroviruses. The recombination analysis indicated that the recombination events were occurred in ORF 2 region (4,444-5,323 nt) in PAstV 5-HNPDS-01 strain. Subsequently, the pathogenicity of PAstV 5-HNPDS-01 was evaluated in 5-day-old piglets. It showed that the PAstV 5-HNPDS-01 could cause mild diarrhea, growth retardation, minor damage to intestinal villi clinically. Meanwhile, PAstV 5-HNPDS-01 infection could affect the microbiota diversity and composition of cecum in piglet from phylum to genus level. After infected with PAstV 5, there was a significant downregulation of beneficial bacteria, including
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