ArticleTransboundary and emerging diseases2024
Characterization and Pathogenicity of a Porcine Reproductive and Respiratory Syndrome Virus Strain with Strong Homology to a HP-PRRSV Vaccine Strain in the Field.
Article in Transboundary and emerging diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Genetic and Respiratory Pathogenic Comparison of Two PRRSV-2 Isolates Classified as Lineage Korean A and B.Transboundary and emerging diseases · 2026Article
- Genetic and Pathogenic Characteristics of an Emerging Lineage 7 PRRSV-2 (Prime Pac-Like) Strain in China.Transboundary and emerging diseases · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A PRRSV strain, PRRSV2/CN/FJLX06/2021, with strong homology to an MLV-like strain HeN1201 that evolved from the highly pathogenic PRRSV vaccine virus HuN4-F112, was isolated from a dying piglet in China. BLAST and phylogenetic analyses showed that PRRSV2/CN/FJLX06-2021 was most closely related to HeN1201 and HuN4 (the parental strain of MLV HuN4-F112) and clustered with Chinese HP-PRRSV strains in PRRSV-2 lineage 8.7. Importantly, 29 of the 39 characteristic amino acid mutations in the HuN4-F112 genome were found at the corresponding sites of PRRSV2/CN/FJLX06-2021. Animal studies showed that piglets infected with PRRSV2/CN/FJLX06-2021 had a persistent high fever, higher viremia, presence of interstitial pneumonia, and a higher mortality rate (40%) within 2 weeks than those vaccine-inoculated with HuN4-F112. Taken together, these data suggest that PRRSV2/CN/FJLX06-2021 is an MLV-like strain that has evolved from MLV HuN4-F112 and is highly pathogenic to piglets.
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