Evidence map›Paper›PMID 40303152›Full record

ArticleTransboundary and emerging diseases2024

Genomic Characterization of HLJDZD55: The First L1B PRRSV in China.

Jinhao Li, Hu Xu, Chao Li, Jing Zhao, Bangjun Gong, Qi Sun, Zhenyang Guo, Siyu Zhang, Menglin Zhang, Lirun Xiang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

20 authors.

Jinhao LiState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Hu XuState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Chao LiState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Jing ZhaoState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Bangjun GongState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Qi SunState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Zhenyang GuoState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Siyu ZhangState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Menglin ZhangState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Lirun XiangState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Yan-Dong TangState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Jianan WuState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Qian WangState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Jinmei PengState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.ORCID https://orcid.org/0000-0001-6943-6898
Guohui ZhouState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Huairan LiuState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Tongqing AnState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.ORCID https://orcid.org/0000-0003-4619-4587
Xuehui CaiState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.
Zhi-Jun TianState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.ORCID https://orcid.org/0000-0003-4254-7891
Hongliang ZhangState Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150001China.ORCID https://orcid.org/0000-0003-0705-6800

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) critically threatens the pig industry in China. Lineage 1 PRRSV, which is divided into L1A-L1F and L1H-L1J, is widely recognized as the most extensively genetically diverse lineage globally. L1A (NADC34-like) and L1C (NADC30-like) PRRSVs have become the current major circulating strains in China. Notably, strains from other branches of L1 have not been reported in China. During our epidemiological investigation of PRRSV, we identified a new strain named HLJDZD55. Phylogenetic analysis of the ORF5 gene revealed that HLJDZD55 belongs to the L1B branch. Alignment of deduced amino acid sequences based on the Nsp2 gene indicated that HLJDZD55 has a discontinuous deletion of 131 amino acids (111 + 1 + 19). We further sequenced the whole genome of HLJDZD55, and phylogenetic analysis based on the whole-genome sequence revealed that HLJDZD55 belongs to the L1C branch. Recombination analysis of the whole genome demonstrated that HLJDZD55 is a recombinant strain of TJZH-1607 (L1C, identified in China) and Minnesota 14 (L1B, identified in the USA). These findings suggested that HLJDZD55 is a newly emerged lineage 1 PRRSV in China and is closely related to L1B PRRSV in the US, which may have been introduced from the U.S. strain and subsequently recombined with the local Chinese strain and underwent evolution. Taken together, these results demonstrated the emergence of L1B PRRSV in China for the first time.

Indexed as

Genome, ViralPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusAnimalsChinaPhylogenySwine

Identifiers

PMID40303152
PMCPMC12020383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.