Evidence map›Paper›PMID 40303006›Full record

ReviewJournal of inflammation research2025

The Role of NLRP3 Inflammasome in Oral Squamous Cell Carcinoma.

Rui Shi, Xuan Zhuang, Tong Liu, Song-Nan Yao, Feng-Shan Xue

Abstract readReview
In one paragraph

Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui ShiDepartment of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University 266600, Qingdao, 266555, People's Republic of China.
Xuan ZhuangCardiac Surgery Intensive Care Unit Department, the Affiliated Hospital of Qingdao University, Qingdao, 266555, People's Republic of China.
Tong LiuThe Affiliated Tai'an City Central Hospital of Qingdao University, Taian, 271000, People's Republic of China.
Song-Nan YaoCardiac Surgery Intensive Care Unit Department, the Affiliated Hospital of Qingdao University, Qingdao, 266555, People's Republic of China.
Feng-Shan XueCardiac Surgery Intensive Care Unit Department, the Affiliated Hospital of Qingdao University, Qingdao, 266555, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck. More and more evidence emphasizes the importance of inflammation in the progression of OSCC. The main signaling pathway of acute and chronic inflammation consists of the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome. Objective: This review focuses on the role of NLRP3 immune kinase body and giving a contribution to the development of new treatment strategies against OSCC. Conclusion: The NLRP3 inflammasome plays a vital role in the pathogenesis and development of OSCC and may serve as a promising therapeutic target for autoimmune diseases.

Indexed as

autophagy5Caspase-13GSDMD4NLRP31oral squamous cell carcinoma 2

Identifiers

PMID40303006
PMCPMC12039833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.