ArticleJournal of inflammation research2025
Coagulation and Inflammatory Indicators in Pneumonia Patients with Venous Thromboembolism: A Propensity-Score Matching Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Age-dependent patterns of D-dimer and APTT for VTE in severe pneumonia: a multicenter retrospective study.Thrombosis journal · 2026Article
- A multimarker panel for diagnosis and prognosis prediction of fungal infections.Clinical and experimental medicine · 2026Article
- Identification of early diagnostic biomarkers in venous thromboembolism: A bioinformatic analysis based on crosstalk between pyroptosis and venous thromboembolism.Experimental and therapeutic medicine · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Venous thromboembolism (VTE) is associated with high morbidity and mortality. In recent years, increasing evidence has suggested that inflammation plays a critical role in the pathogenesis of VTE. Patients with pneumonia often exhibit an inflammatory response. This study aimed to investigate the correlation between inflammatory indicators and VTE by analyzing laboratory indicators in patients with pneumonia and VTE. Methods: Samples were collected from patients with pneumonia admitted between December 2022 and March 2023. Patients were classified into the VTE and non-VTE groups according to whether they had VTE or not. Propensity score matching (PSM) was performed to control for potential confounding factors. Coagulation and inflammatory indicators were measured. Statistical analyses were performed to identify biomarkers that exhibited significant differences between the two groups, and the relationship between coagulation and inflammatory indicators was further explored. Results: D-dimer, thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin complex (PIC), t-PA:PAI-1 complex (tPAIC), and thrombomodulin (TM) levels were significantly higher in the VTE group. White blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), procalcitonin (PCT), and C-reactive protein (CRP) levels were significantly elevated in VTE group. The areas under the curve (AUC) of the receiver operator characteristic (ROC) curves for D-dimer, TAT, PIC, tPAIC, and TM were 0.806, 0.691, 0.656, 0.621, and 0.641, respectively, while the areas for WBC, NLR, CRP, and PCT were 0.690, 0.647, 0.618, and 0.651, respectively. Correlation analysis revealed that WBC was significantly correlated with D-dimer, TAT, PIC and TM. NLR was correlated with D-dimer and TM. CRP was correlated with D-dimer and TM. Conclusion: There is a significant activation of both coagulation and fibrinolytic systems in pneumonia patients. VTE in pneumonia patients is associated with the activation of inflammatory system. Monitoring inflammatory and coagulation indicators in pneumonia patients can facilitate early identification of individuals at an elevated risk of VTE.
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